NU5M_ORNAN
ID NU5M_ORNAN Reviewed; 604 AA.
AC Q36459;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Ornithorhynchus anatinus (Duckbill platypus).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000312|Proteomes:UP000002279};
RX PubMed=8919867; DOI=10.1007/bf02198841;
RA Janke A., Gemmell N.J., Feldmaier-Fuchs G., von Haeseler A., Paabo S.;
RT "The mitochondrial genome of a monotreme--the platypus (Ornithorhynchus
RT anatinus).";
RL J. Mol. Evol. 42:153-159(1996).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03915}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03915};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03920}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; X83427; CAA58452.1; -; Genomic_DNA.
DR PIR; C58889; C58889.
DR RefSeq; NP_008053.1; NC_000891.1.
DR AlphaFoldDB; Q36459; -.
DR SMR; Q36459; -.
DR STRING; 9258.ENSOANP00000024987; -.
DR Ensembl; ENSOANT00000028486; ENSOANP00000024987; ENSOANG00000019362.
DR GeneID; 808701; -.
DR KEGG; oaa:808701; -.
DR CTD; 4540; -.
DR eggNOG; KOG4668; Eukaryota.
DR GeneTree; ENSGT00730000111303; -.
DR InParanoid; Q36459; -.
DR OrthoDB; 526738at2759; -.
DR Proteomes; UP000002279; Mitochondrion.
DR Bgee; ENSOANG00000019362; Expressed in heart and 6 other tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0003954; F:NADH dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..604
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118121"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 481..501
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 584..604
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 604 AA; 67439 MW; CEE5338A73E2A1DC CRC64;
MNLLFFSSLL TALIILCIPL LLSFTPYYKL ENYPHHVKTM IMWSFIISLV PMLSFLNGGV
EATVTNWHWF TTQTFNLSMN FKLDLYTIMF LPIALLITWS IMEFSIWYMS SDPKINQFMK
YLLIFLITML TLISANNLFQ LFIGWEGVGI MSFMLIGWWH ARTDANTAAL QAILYNRIGD
IGFILAMAWF LIHTNSWEFQ QMFLLHTNLL PLLGLILAAT GKSAQFGLHP WLPFAMEGPT
PVSALLHSST MVVAGIFLLV RFSPLLEQNS TALTMALCLG AITTLFTAAC ALTQNDIKKI
IAFSTSSQLG LMMVTIGLNQ PFLAFLHICT HAFFKAMLFL CSGSIIHNLN DEQDIRKMGG
LINILPITSS ALIIGSLALT GMPFLAGFYS KDLIIESLNT SNTNAWALSL TLVATTFTAV
YSTRVIFLAL LNQPRFSPAS SINENNPLLI NPIKRLAIGS ILAGFLLTSY INPTTLTPTT
MPPFIKVTAL VITILGFILA LELYLTTNNL TLKPHSQLHT FSNLLGYFPL IMHRKPTAQN
FFLGQNMATM LIDLTWFEKS GPKGISSHQL TILTSVTEAQ KGLMKIYFLS FLITPPIIIT
LLLF
