NU5M_OSPRO
ID NU5M_OSPRO Reviewed; 602 AA.
AC P92669;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Osphranter robustus (Wallaroo) (Macropus robustus).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Diprotodontia; Macropodidae; Osphranter.
OX NCBI_TaxID=9319;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9037043; DOI=10.1073/pnas.94.4.1276;
RA Janke A., Xu X., Arnason U.;
RT "The complete mitochondrial genome of the wallaroo (Macropus robustus) and
RT the phylogenetic relationship among Monotremata, Marsupialia, and
RT Eutheria.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:1276-1281(1997).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03915}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03915};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03920}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; Y10524; CAA71546.1; -; Genomic_DNA.
DR PIR; T11438; T11438.
DR RefSeq; NP_007404.1; NC_001794.1.
DR AlphaFoldDB; P92669; -.
DR SMR; P92669; -.
DR GeneID; 808072; -.
DR CTD; 4540; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..602
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118110"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..428
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 481..501
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 582..602
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 602 AA; 67541 MW; 56E6E41D5F4C8DA8 CRC64;
MNFIFNSSML LAITMLTFPL IYNLAFPDKT NNFPLYCKTT VKMAFFTSLP ALLLFINTGQ
ESTITNWQWF SIESLNMTMS FKLDYFSIIF IPIALYVTWS ILEFSLWYMH SDPYIHRFFK
YLITFLLTMI ILVSANNLFQ LFIGWEGVGI MSFMLIGWWF GRTDANTAAL QAVLYNRIGD
IGFMLAMAWL MINNSSWDLQ HIFMTNMDTL ALMGLVIAAT GKSAQFGLHP WLPSAMEGPT
PVSALLHSST MVVAGIFLLI RFHPMIKDNP TILTTTLCLG AITTLFTAIC AITQNDIKKI
VAFSTSSQLG LMMVTIGLNQ PYLAFLHICT HAFFKAMLFL CSGSIIHNLN DEQDIRKMGG
LLNIMPITSS ALITGSLALM GTPFLAGFYS KDSIIEAMNT SHTNTWALII TLIATALTAI
YSLRIIYFAL LNQPRFLPMS PINENHPNLT NPIIRLAMGS IFAGFILTMN IPPTSMVPLT
MPPISKLSAL IVTITGLLIA MELNSATNKS LMMSYIHTHN FSNMLGYFTY LFHRMYPLAN
LYLGQHIATM LIDLNWYEKT GPKGQANLHS TISSYISSTQ KGLIKTYFLS FIISIPMIML
II
