NU5M_PANPA
ID NU5M_PANPA Reviewed; 603 AA.
AC P03916; Q35589;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7530363; DOI=10.1073/pnas.92.2.532;
RA Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N.;
RT "Recent African origin of modern humans revealed by complete sequences of
RT hominoid mitochondrial DNAs.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-79.
RX PubMed=6284948; DOI=10.1007/bf01734101;
RA Brown W.M., Prager E.M., Wang A., Wilson A.C.;
RT "Mitochondrial DNA sequences of primates: tempo and mode of evolution.";
RL J. Mol. Evol. 18:225-239(1982).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03915}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03915};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03920}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; D38116; BAA07315.1; -; Genomic_DNA.
DR EMBL; V00672; CAA24043.1; -; Genomic_DNA.
DR PIR; A05226; A05226.
DR PIR; T14149; T14149.
DR RefSeq; NP_008209.1; NC_001644.1.
DR AlphaFoldDB; P03916; -.
DR SMR; P03916; -.
DR Ensembl; ENSPPAT00000000032; ENSPPAP00000000011; ENSPPAG00000000032.
DR GeneID; 807878; -.
DR KEGG; pps:807878; -.
DR CTD; 4540; -.
DR GeneTree; ENSGT00730000111303; -.
DR OMA; GVGIMSF; -.
DR OrthoDB; 526738at2759; -.
DR Proteomes; UP000240080; Chromosome, Mitochondrial.
DR Bgee; ENSPPAG00000000032; Expressed in adult mammalian kidney and 6 other tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..603
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118122"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..429
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 482..502
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 583..603
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 603 AA; 67438 MW; D67AD06DED8ABA37 CRC64;
MTMYTTMTTL TLTPLILPIL TTLINPNKKN SYPHYVKSII ASTFIISLFP TTMFMCLDQE
AIISNWHWAT TQTTQLSLSF KLDYFSMTFI PVALFVTWAI MEFSLWYMNS DPNINQFFKY
LLIFLITMLI LVTANNLFQL FIGWEGVGIM SFLLISWWYA RTDANTAAIQ AILYNRIGDI
GFILALAWFL LHSNSWDPQQ MVLLSTNPSL TPLLGFLLAA AGKSAQLGLH PWLPSAMEGP
TPVSALLHSS TMVVAGVFLL IRFHPLAENN PLIQTLTLCL GAITTLFAAI CALTQNDIKK
IVAFSTSSQL GLMMVTIGIN QPHLAFLHIC THAFFKAMLF MCSGSIIHNL NNEQDIRKMG
GLLKTMPLTS TSLIIGSLAL AGMPFLTGFY SKDLIIETAN MSYMNAWALS ITLIATSLTS
AYSTRMILLT LMGQPRFPTL TNINENNPTL LNPIKRLTIG SLFAGFFITN NILPMSTSQM
TIPLYLKLTA LSVTFLGLLT ALDLNYLTNK LKMKSPPYTF YFSNMLGFYP NIMHRSIPYL
GLLTSQNLPL LLLDLTWLEK LLPKTISQYQ VSASITTSTQ KGMIKLYFLS FLFPLILTLL
LIM
