NU5M_PAPHA
ID NU5M_PAPHA Reviewed; 603 AA.
AC Q95885;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1999, sequence version 2.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Papio hamadryas (Hamadryas baboon).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9557;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9847414; DOI=10.1007/pl00006431;
RA Arnason U., Gullberg A., Janke A.;
RT "Molecular timing of primate divergences as estimated by two nonprimate
RT calibration points.";
RL J. Mol. Evol. 47:718-727(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-79.
RX PubMed=8752012; DOI=10.1093/oxfordjournals.molbev.a025655;
RA Hayasaka K., Fujii K., Horai S.;
RT "Molecular phylogeny of macaques: implications of nucleotide sequences from
RT an 896-base pair region of mitochondrial DNA.";
RL Mol. Biol. Evol. 13:1044-1053(1996).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03915}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03915};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03920}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; Y18001; CAA77004.1; -; Genomic_DNA.
DR EMBL; D85290; BAA12792.1; -; Genomic_DNA.
DR PIR; T11516; T11516.
DR RefSeq; NP_008468.1; NC_001992.1.
DR AlphaFoldDB; Q95885; -.
DR SMR; Q95885; -.
DR GeneID; 808320; -.
DR CTD; 4540; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..603
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118124"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 406..422
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 583..603
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 603 AA; 67674 MW; 0E744728381C3BFB CRC64;
MAMYTSIMLM TLASLALPIF ATLVNPNKTH SYPNYVKTTM MYAFITSLIP TTLYIFSNQE
TTIWSWHWMM TQTLDLTLSF KLDYFSMMFI PIALFITWSI MEFSLWYMSS DPNINQFFKY
LLIFLITMLI LITANNLFQL FIGWEGVGIM SFLLISWWHA RTDANTAAIQ AVLYNRIGDI
GLILAMVWFL LHYNSWDFQQ MLALNPHPSP LPLMGLLLAA VGKSAQFGLH PWLPSAMEGP
TPVSALLHSS TMVVAGVFLL IRFHPLMEND TLTQNLTLCL GAITTLFMAM CALTQNDIKK
IVAFSTSSQL GLMMITIGIN QPYLAFLHIC THAFFKAMLF ICSGSIIHNL NNEQDIRKMG
GLFKTMPLTS TSLIIGNLAL TGIPFLTGFY SKDLIIEATS TSYTNAWALS ITLIATSLTS
AYSTRTILLT LTGQPRFPTL TNINENNPAL LNPIKRLTTA SMITGFLITN NIPPTSLPQP
TMPLHLKLLA LYMTALGFII TLDLTLMTNK LKVKTPPQTF KFSNMLGYFP TIAHRMIPHQ
NLLMSQNLAL LLLDSMWLEK SMPKMISQTH ITASTTVTAQ KSMIKLYFLS FLIPLALALL
LMV
