ID   NU5M_PARLI              Reviewed;         638 AA.
AC   P12776;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 5;
GN   Name=ND5;
OS   Paracentrotus lividus (Common sea urchin).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Echinidae; Paracentrotus.
OX   NCBI_TaxID=7656;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2544576; DOI=10.1016/s0021-9258(18)60413-2;
RA   Cantatore P., Roberti M., Rainaldi G., Gadaleta M.N., Saccone C.;
RT   "The complete nucleotide sequence, gene organization, and genetic code of
RT   the mitochondrial genome of Paracentrotus lividus.";
RL   J. Biol. Chem. 264:10965-10975(1989).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR   EMBL; J04815; AAA68143.1; -; Genomic_DNA.
DR   PIR; B34285; B34285.
DR   RefSeq; NP_008131.1; NC_001572.1.
DR   AlphaFoldDB; P12776; -.
DR   SMR; P12776; -.
DR   GeneID; 807710; -.
DR   CTD; 4540; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR010934; NADH_DH_su5_C.
DR   InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR003945; NU5C-like.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   PANTHER; PTHR42829; PTHR42829; 1.
DR   Pfam; PF06455; NADH5_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
DR   TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..638
FT                   /note="NADH-ubiquinone oxidoreductase chain 5"
FT                   /id="PRO_0000118125"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        335..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        404..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        445..465
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        487..507
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        520..540
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        618..638
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   638 AA;  69245 MW;  6A614A722848917F CRC64;
     MVINPSTIVS TLSMSIMAIL AVSIFFFSKS YFYPPQNNNL VSFRVSNDTL SNNPNGSSLD
     YNSGPFAISV LKTLAFLSVI SLLISVQNSF KSINLTFSLW FNNTPTNVSI NFLLDQYFLL
     FLSVGLIVTW SIMEFSYYYM KEDPNGKAFF RPFGHFSLNM LILTSSNSLF LVFLGWEGVG
     FLSFLLISWW ATRNDASSSA LEAVIYNRIG DIGLITFMSL AVLTTNSWNL TEIITNEPNN
     HFVLFMLFGL ILAAAGKSAQ FGLHPWLPAA MEGPTPVSAL LHSSTMVVAG VFLLVRTSEL
     FSNYPNANTI VLVLGGTTAL FAASTAIAQH DIKKIIAYST TSQLGLMVAA IGIGQPVLAF
     FHICTHAFFK AMLFLCLGSV IHSLNNERNL RKMEGISDLS PVTSACLAMG SLALMGTPFL
     AGFYSKDLIL EAASASFANT LGISLGIVAT MLTTVYSFRI VFFCFSSNNS ISPLSPIGEE
     NSNLINALLR LSIGTILSGW FFSNFIFSPP SFTVTPEEKG LPLLVTVVGL TVIFISLSYL
     SSNPIKSTSH STTTSQWFFV DIVHSALTTT SFISSSFSSS RTLDRGWQEN IGAQGIAQSS
     TALSKANQAS QIGLIKRYIA SSIAAITIIA TLTFIVLS