NU5M_PATPE
ID NU5M_PATPE Reviewed; 643 AA.
AC P11993; Q33816;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 2.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=ND5;
OS Patiria pectinifera (Starfish) (Asterina pectinifera).
OG Mitochondrion.
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Asterozoa; Asteroidea;
OC Valvatacea; Valvatida; Asterinidae; Patiria.
OX NCBI_TaxID=7594;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Ovary;
RX PubMed=7672576; DOI=10.1093/genetics/140.3.1047;
RA Asakawa S., Himeno H., Miura K., Watanabe K.;
RT "Nucleotide sequence and gene organization of the starfish Asterina
RT pectinifera mitochondrial genome.";
RL Genetics 140:1047-1060(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-515.
RX PubMed=3678836; DOI=10.1016/0378-1119(87)90139-9;
RA Himeno H., Masaki H., Kawai T., Ohta T., Kumagai I., Miura K., Watanabe K.;
RT "Unusual genetic codes and a novel gene structure for tRNA(AGYSer) in
RT starfish mitochondrial DNA.";
RL Gene 56:219-230(1987).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA65517.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; D16387; BAA03875.2; -; Genomic_DNA.
DR EMBL; M17619; AAA65517.2; ALT_INIT; Genomic_DNA.
DR PIR; S70592; S70592.
DR RefSeq; NP_008163.2; NC_001627.1.
DR AlphaFoldDB; P11993; -.
DR SMR; P11993; -.
DR GeneID; 807825; -.
DR CTD; 4540; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..643
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118065"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 437..457
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 486..506
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 511..531
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 555..575
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 615..635
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 643 AA; 71300 MW; 1E7B320A73D62685 CRC64;
MNINPSIIIL TINISIIITL LSSVFFFQNE TNPSNLNSSS YSLGIFHNTS FNYLFSNSLF
FTSLLKTLAI LSLFPLFIEI IFNIPDTTVS LFNWLPNNGF SLNVEFRFDL KFNTFLSVAL
IVSWSILEFS YYYMDNDPNP NNFFRLLIIF LLNMIILTST NNIFLLFIGW EGVGFLSFLL
ISWWTSRANA NNSAIQAVIY NRVGDIGILL FFSLSITLFN TWSLPEIFSI SAPNTFNNLL
LVGLLIAAAG KSAQFGLHPW LPAAMEGPTP VFSIRHSSTM VVAGIFLLIR LSPLYACSSN
FNTWCLILGS ITAIFAATTA ISQHDIKKIV AYSTTSQLGL MMVAIGLNQP SIALFHICTH
AFFKAMLFLS SGSIIHSLND EQDIRKMGGL HFILPNTAAC IILGSLALSG IPFLPGFYSK
DLILEIGLTN FSNFMGIVLS LLATLLTSVY SFRIIFFCFI KNPSFSPLAP INEENNNLTN
SLNRLALGTI LSGWILTNLT VLVPIITISS VLKTAALLLT ITGVLFSISI LQELTLNISP
PTAYNTNSFT TNQWFYENIS HILFLFYSFT ISLSLSTRNI DRGWSENIGA QGIAITSSNA
SQSYQLSQTG YIKQYLLFSF LTLLIIIALS LTTISQLSPS FDI
