NU5M_PELSU
ID NU5M_PELSU Reviewed; 605 AA.
AC O79678;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Pelomedusa subrufa (African side-necked turtle).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Pleurodira; Pelomedusidae;
OC Pelomedusa.
OX NCBI_TaxID=44522;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9826682; DOI=10.1073/pnas.95.24.14226;
RA Zardoya R., Meyer A.;
RT "Complete mitochondrial genome suggests diapsid affinities of turtles.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:14226-14231(1998).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; AF039066; AAD05058.1; -; Genomic_DNA.
DR PIR; T11111; T11111.
DR RefSeq; NP_008442.1; NC_001947.1.
DR AlphaFoldDB; O79678; -.
DR SMR; O79678; -.
DR GeneID; 808282; -.
DR CTD; 4540; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..605
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118128"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 371..391
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 584..604
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 605 AA; 67637 MW; F5E55ECCE478FC67 CRC64;
MPNLQLILKT ILITELLILA LSALMTMLPP ILNKLTWDPE KAMTTTFRLS LTSILIHILI
EEPSSISSLY SPTMLNLAMS IKIDYYSLIF ISIALFITRA ILQYTKWYMA SDRDLKKFSM
FLLLFLMSMI MFIAANNFFP MLVGWGTMGL MSYLLISWWH GRTEATTSGL QAILYNRLAD
IGFILTFSWC ITYMSSLDLN TFFATSTLVT GVPILGMLMA AMGKSAQFGM HPWLPAAMEG
PTPVSALLHS STMVTAGVYL LIGMHPILSQ TQGFSEACLT MGAATALYAS FKALLQNDLK
KIIAFSTLSQ LGFMMATVGL NHPNLAFMHL CMHAFFKAMM FLCAGSISHA LFGEQDIRKM
SGMIKVTPIT ASCFTLSTLA LAGFPFLTGF FSKDLIIETI LLSKINMLWA TMLLISTMFT
AIYSLRMTLR ILTGTPWYND LLTYEENPTC TKPIMKLALA SIVTGSLFSL FTPPIYTPLQ
TMPPTIKLAA LTLTFMSAFL AMYLISLANN KPLPKNTIQN HMLQTAKDLK IITHRHLMAK
LLKASQKTAL QILDNHWKLK AGPKYIEKTQ IPMSMKTSTQ SGLIKTYFMA FLVTFVIILY
IMLFY
