NU5M_PETMA
ID NU5M_PETMA Reviewed; 598 AA.
AC Q35543;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Petromyzon marinus (Sea lamprey).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7713438; DOI=10.1093/genetics/139.2.873;
RA Lee W.J., Kocher T.D.;
RT "Complete sequence of a sea lamprey (Petromyzon marinus) mitochondrial
RT genome: early establishment of the vertebrate genome organization.";
RL Genetics 139:873-887(1995).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; U11880; AAB08748.1; -; Genomic_DNA.
DR PIR; S55014; S55014.
DR RefSeq; NP_008158.1; NC_001626.1.
DR AlphaFoldDB; Q35543; -.
DR SMR; Q35543; -.
DR STRING; 7757.ENSPMAP00000011441; -.
DR Ensembl; ENSPMAT00000014138; ENSPMAP00000011441; ENSPMAG00000013111.
DR GeneID; 807813; -.
DR CTD; 4540; -.
DR GeneTree; ENSGT00730000111303; -.
DR HOGENOM; CLU_007100_6_0_1; -.
DR OMA; GVGIMSF; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..598
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118130"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 478..498
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 576..596
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 598 AA; 67079 MW; 67AE1158937D4897 CRC64;
MNSHYLTLIM NSGALLTIIV LLPPIIMPKP SMILTTKLVK ISMFISLIPL TIYLNENMET
TLTMKPWMDW ALFNIALSFK IDKYTVIFTP IALMITWSIM EFSQWYMAKE RHMDKFFKYL
LLFLITMITF ISANNLLQLF IGWEGVGIMS FLLISWWSGR TKANISALQA VAYNRIGDIG
LMMSMVWMCS NTNSWDLQQI TMLLSDQQYL IPTLGFLIAA TGKSAQFGLH PWLPAAMEGP
TPVSALLHSS TMVVAGVFLL IRLHPLFQNY PLMLEMTLCL GAMTTICAAL CATTQNDIKK
IIAFSTSSQL GLMMVAVGLN HPHIAFLHMC THAFFKAMLF LCSGSIIHNM NNEQDIRKFS
CLNNNLPLTT TCMTIGSAAL MGLPFLAGFF TKDLILEALN TSYTNAWALM VTLMAVTLTT
AYSSRLIIMS ASGTPRYLPL TPTHENNFIK NPLKRLAWGS LISGLILTST LPPMKPQIFT
MPTYIKTIAL MMFIISLIIS MELTNKKINQ TTFSFFTQLA FYPHIIHRLT SHLSLIWSQK
LMTQVMDVSW LEKIGPKGLA NHQLKPSTTL TEAHHLNSAT LPLMAFALTL ITLSLTAR
