NU5M_PHYIN
ID NU5M_PHYIN Reviewed; 664 AA.
AC P50366;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=ND5; Synonyms=NAD5;
OS Phytophthora infestans (Potato late blight agent) (Botrytis infestans).
OG Mitochondrion.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4787;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 16981 / West Virginia 4;
RA Lang B.F., Forget L.;
RT "The mitochondrial genome of Phytophthora infestans.";
RL (In) O'Brien S.J. (eds.);
RL Genetic maps, pp.3:133-135, Cold Spring Harbor Laboratory Press, New York
RL (1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 16981 / West Virginia 4;
RA Paquin B., Roewer I., Wang Z., Lang B.F.;
RT "A robust fungal phylogeny using the mitochondrially encoded nad5 protein
RT sequence.";
RL Can. J. Bot. 73:S180-S185(1995).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; U17009; AAA99061.1; -; Genomic_DNA.
DR PIR; T14132; T14132.
DR RefSeq; NP_037615.1; NC_002387.1.
DR AlphaFoldDB; P50366; -.
DR SMR; P50366; -.
DR GeneID; 808860; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..664
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118132"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 521..541
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 590..610
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 614..634
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 639..659
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 664 AA; 76150 MW; 1C94B4E9E9F185C3 CRC64;
MLLLTLIFLP FLGSVAAGLF GFYIGRKGSV FITTLTTFLS CIFSLIIIYN SITNEYEYII
YISNWINSGL FNCNWCFLFD SLTMIMLVVV TSISTLVHLY SSQYMAHDPH LSRFMSYLSL
FTFFMIILVT GDNFMQMFVG WEGVGFCSYL LINFWFTRLQ ANKAAIKAML VNRISDLILL
LGVLTIFYNI RTIEYFSTFA AISIVKDFKF IFFNYILSII DVACILIFIG AMGKSAQIFL
HLWLPDAMEG PTPVSALIHA ATMVTAGVYL TARCSPMFEY SMFSLKIITI IGASTAFFAS
TVGLVQNDFK KIVAYSTCSQ LGYMFFACGL SNYPLAIFHL SNHAYFKALL FLCSGAVIHA
MGDEQDIRKM GGLRRILPFT YIMFLIGSLS LMGFPFLTGF YSKDLILEVA FASFSETGHF
AYWLGTIGAF FTAFYSTRLL FFAFLSETNA YKNIIKNAHD VPLEMGIPLG LLAFGSIFIG
YISKDMFVGL GSDFWNNSIY INPFNNQMID AEFLPTFFKL LPVILSFCGL FGAFYLYFFK
FKFLYNLKIS EYGLYFYNFL NRKWYFDKIY YEFINQYILK IGYNVTYKMI DKGLIEMCGP
YGLTTIFSFL SQQIILLQTG YIYHYSLLML ISTIFLINII FFSIIYYFNI ITILLFLFIF
LLIK
