NU5M_PODAN
ID NU5M_PODAN Reviewed; 652 AA.
AC P20679;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=ND5;
OS Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)
OS (Pleurage anserina).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Podosporaceae; Podospora;
OC Podospora anserina.
OX NCBI_TaxID=515849;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=A, and s;
RX PubMed=2319602; DOI=10.1016/0022-2836(90)90124-5;
RA Cummings D.J., Michel F., Domenico J.M., McNally K.L.;
RT "DNA sequence analysis of the mitochondrial ND4L-ND5 gene complex from
RT Podospora anserina. Duplication of the ND4L gene within its intron.";
RL J. Mol. Biol. 212:269-286(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=s;
RX PubMed=2357736; DOI=10.1007/bf00334517;
RA Cummings D.J., McNally K.L., Domenico J.M., Matsuura E.T.;
RT "The complete DNA sequence of the mitochondrial genome of Podospora
RT anserina.";
RL Curr. Genet. 17:375-402(1990).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; X55026; CAA38798.1; -; Genomic_DNA.
DR PIR; S09133; S09133.
DR RefSeq; NP_074943.1; NC_001329.3.
DR AlphaFoldDB; P20679; -.
DR SMR; P20679; -.
DR STRING; 515849.P20679; -.
DR GeneID; 802446; -.
DR KEGG; pan:PoanfMp36; -.
DR Proteomes; UP000001197; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..652
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118136"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..474
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 505..525
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 619..639
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 652 AA; 72633 MW; 84CA887B75755FE8 CRC64;
MYLSIIILPL LGCIVSGFLG RKVGVKGAQL ITCSNVVITT ILSILAFIEV GFNNIPVTIN
LFRWIDSEWF NIIWGFQFDS LTVSMLIPVL IISSLVHIYS ISYMSSDPHN QRFFSYLSLF
TFMMIILVTA NNYLLMFVGW EGVGVCSYLL VSFWFTRIAA NQSSISAFLA NRVGDCFLTI
GMFAILWSLG NLDYSTVFSL APYINSKVVL IIGICLLIGA MAKSSQVGLH VWLPMAMEGP
TPVSALIHAA TMVTAGVYLL MRSSPLIEYN STVLLLCLWL GAITTVFSSL IGLFQQDIKK
VIAYSTMSQL GMMVIAIGLS SYNVALFHLI NHAFYKALLF LGAGSVIHAV ADNQDFRKYG
GLINFLPLTY SVMLIASLSL VAFPFMTGFY SKDFILESAY GQFSFSGVAV YIIATIGAIF
TTLYSVKVLY LTFLSNPNGT RAYYNYKPAL EGDLFLTLPL IILAIFSIFF GFITKDIFIG
LGSNFFGDNS LFIHPTHEIM IDTEFAVPVL FKLLPFIFTI SFSIIALTIS EFLSELVIYF
KLSRLGYNIF GFFNQRFLIE LFYNKYITNL ILDLGGQMTK ILDKGSIELF GPFGLEKGLV
NFSKNISSLS TSHVTTYALY ILVAFILYLL YNYLSFNFLP FLIAGLTILT TI
