NU5M_RABIT
ID NU5M_RABIT Reviewed; 603 AA.
AC O79437;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Oryctolagus cuniculus (Rabbit).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000312|Proteomes:UP000001811};
RX PubMed=9653643; DOI=10.1006/geno.1998.5282;
RA Gissi C., Gullberg A., Arnason U.;
RT "The complete mitochondrial DNA sequence of the rabbit, Oryctolagus
RT cuniculus.";
RL Genomics 50:161-169(1998).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03915}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03915};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03920}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; AJ001588; CAA04857.1; -; Genomic_DNA.
DR PIR; T11490; T11490.
DR RefSeq; NP_007559.1; NC_001913.1.
DR AlphaFoldDB; O79437; -.
DR SMR; O79437; -.
DR STRING; 9986.ENSOCUP00000026189; -.
DR PRIDE; O79437; -.
DR Ensembl; ENSOCUT00000033137; ENSOCUP00000026189; ENSOCUG00000029112.
DR GeneID; 808224; -.
DR KEGG; ocu:808224; -.
DR CTD; 4540; -.
DR eggNOG; KOG4668; Eukaryota.
DR GeneTree; ENSGT00730000111303; -.
DR HOGENOM; CLU_007100_6_0_1; -.
DR InParanoid; O79437; -.
DR OMA; GVGIMSF; -.
DR OrthoDB; 526738at2759; -.
DR Proteomes; UP000001811; Mitochondrion.
DR Bgee; ENSOCUG00000029112; Expressed in prefrontal cortex and 16 other tissues.
DR ExpressionAtlas; O79437; baseline.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..603
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118140"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 482..502
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 582..602
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 603 AA; 67389 MW; 45FE17EBB7CECC17 CRC64;
MNLFSTSVAV SIIILVLPIV ASFTNIFNSP NYPHYVKTSV SYAFTISLIP TLIFIATSQE
MMVSNWHWMT IHTLKLTTSF KLDYFSMLFT PIALFVTWSI MEFSMWYMHS DPKINQFFKY
LLMFLITMLI LVTANNMFQL FIGWEGVGIM SFLLIGWWHG RTDANTAALQ AILYNRIGDI
GFIMALAWFA INLNTWELQQ IFILDNNITI LPLMGLILAA TGKSAQFGLH PWLPSAMEGP
TPVSALLHSS TMVVAGVFLL IRFYPLLENN KTAQTLILCL GAITTLFTAL CALTQNDIKK
IVAFSTSSQL GLMMVTIGIN QPHLAFLHIC THAFFKAMLF LCSGSIIHSL NDEQDIRKMG
GLYKTMPFTA SALTIGSLAL TGMPFLTGFY SKDLIIESAN TSNTNAWALI ITLIATSLTA
VYSTRIIFFA LLGQPRYPAL IVINENNPLL INSIKRLALG SIFAGFLISN LITPNNVPQM
TMPLYMKMTA LFVTIMGFTI AMELNQLSLS LKMTTQSPYF NFSNMLGFFP MTIHRILPYL
NLSASQNMAT LLLDMTWTEK AIPKNISDIQ IFASTSVSSQ KGLIKLYFLS FLISLLLVLF
ILT
