ID   NU5M_RHISA              Reviewed;         552 AA.
AC   Q9ZYM7;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 5;
GN   Name=ND5;
OS   Rhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Rhipicephalinae;
OC   Rhipicephalus; Rhipicephalus.
OX   NCBI_TaxID=34632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9866211; DOI=10.1093/oxfordjournals.molbev.a025903;
RA   Black W.C. IV, Roehrdanz R.L.;
RT   "Mitochondrial gene order is not conserved in arthropods: prostriate and
RT   metastriate tick mitochondrial genomes.";
RL   Mol. Biol. Evol. 15:1772-1785(1998).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR   EMBL; AF081829; AAD05525.1; -; Genomic_DNA.
DR   PIR; T11161; T11161.
DR   RefSeq; NP_008518.1; NC_002074.1.
DR   AlphaFoldDB; Q9ZYM7; -.
DR   SMR; Q9ZYM7; -.
DR   EnsemblMetazoa; GeneID_808362_df_mr; NP_008518.1; GeneID_808362.
DR   GeneID; 808362; -.
DR   KEGG; rsan:808362; -.
DR   CTD; 4540; -.
DR   VEuPathDB; VectorBase:GeneID_808362; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR003945; NU5C-like.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   PANTHER; PTHR42829; PTHR42829; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..552
FT                   /note="NADH-ubiquinone oxidoreductase chain 5"
FT                   /id="PRO_0000118142"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        447..467
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        532..552
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   552 AA;  64542 MW;  583A74F293F4DEEC CRC64;
     MFINWTMMLI SFSIVFLYMF FMTFYFNIFF IFEYNLMSIL SFEYKFYILL DWMSCMFSFT
     VLMISSMVLW YSHSYMSSDK NKTSFCWMVL MFILSMLLLV LMPNVFMLIL GWDGLGLTSY
     CLVIFYQSSN SYNSGMMTII SNRVGDVMVI MMIIFAINFN SFELTSIKSF ELIWGLLIII
     AGLTKSAQIP FSAWLPAAMA APTPVSALVH SSTLVTAGVY LLIRFDLLFN NNIFSAFLMK
     ISLMTMIMSG MNAFFENDLK KIIAFSTLSQ LSIMMLTLSL SLTNLSFFHL IVHAIFKSML
     FLCAGFVIHN LMGNQDIRFL SDFFKFSPLI LSCMMIGMFS LMGFPFIGGF YSKDVIMEFF
     FLKSNNMIEM NMFIVGIIFT FLYNFRLFYM LLLKGTLFNM MSKDSINIFM NYPIFNLTVY
     LLITSNLMSW LLLPEYTMIF LSFTQKLMLL FLVPFCTFMF MILLKFIKFF PYLKLNFLMT
     MWNLSELTSF IMLSNNKFLL KMSINDWTWL EMYGPLGIKS KIEHNYNFSM TKEINVITIA
     FSLTILMMII VY