NU5M_ROUAM
ID NU5M_ROUAM Reviewed; 605 AA.
AC Q76LN2;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 56.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Rousettus amplexicaudatus (Common rousette).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Rousettus.
OX NCBI_TaxID=58083;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Bastian S.T. Jr., Tanaka K., Anunciado R.P.V., Natural N.G., Sumalde A.C.,
RA Namikawa T.;
RT "Phylogenetic position of the Philippine flying lemur (order Dermoptera)
RT within Eutheria using DNA sequences of Cyt b and ND5 genes.";
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03915}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03915};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03920}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; AB075978; BAC82493.1; -; Genomic_DNA.
DR AlphaFoldDB; Q76LN2; -.
DR SMR; Q76LN2; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..605
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118145"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 482..502
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 584..604
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 605 AA; 67901 MW; F752FF9AB308B469 CRC64;
MNLRTSSTLL SLLILTVPIM ASNFYPYTKK SYPIYVKTMV SYAFLVSLIP TMIFIQSGQE
TMISNWHWMT IQTLKLSLSF KLDYFSMILM PVALSVTWSI MEFSMWYMHS DPYINRFFKY
LLLFLITMML LVTANNLFQL FIGWEGVGIM SFLLIGWWYG RTDANTAALQ AILYNRIGDV
GFLVAMAWFL FNLNTWELQQ IFTLNPTNTN LPLTGLLLAA TGKSAQFGLH PWLPSAMEGP
TPVSALLHSS TMVVAGIFLL IRFYPLTESN KTIQTMMLCL GAITTLFTAI CALTQNDIKK
IVAFSTSSQL GLMMVTVGIN QPHLAFLHIC THAFFKAMLF LCSGSIIHSL NDEQDIRKMG
GLYKSLPFTT TALITGSLAL TGMPFLTGFY SKDLIIESIN TSYTNAWALF ITLIATSLTA
VYSTRIIYFA LLGQPRFPTL ILINEDIPLL INPIKRLLVG SIFAGFFISN NITPTTIPQM
TMPTYLKTTA MLVTLLGFIV ALELNTATQN LKLTPPSNYL KFSNLLGYFP TIMHRLQPLT
SLLTSQKVAS MLLDLAWLEN ALPKSISIFQ MKTSTLISSQ KGQIKLYFLS FLITLTLSLI
MLNFT
