NU5M_SALSA
ID NU5M_SALSA Reviewed; 612 AA.
AC Q9ZZM3; Q9MPG6;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Salmo salar (Atlantic salmon).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Liver;
RX PubMed=10548724; DOI=10.1016/s0378-1119(99)00425-4;
RA Hurst C.D., Bartlett S.E., Davidson W.S., Bruce I.J.;
RT "The complete mitochondrial DNA sequence of the Atlantic salmon, Salmo
RT salar.";
RL Gene 239:237-242(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Arnason U., Johnsson E., Rasmussen A.S.;
RT "The complete mitochondrial genome sequence of a teleost, Salmo salar, and
RT comparisons with other salmoniformes.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; U12143; AAD04743.1; -; Genomic_DNA.
DR EMBL; AF133701; AAF61388.1; -; Genomic_DNA.
DR PIR; T09957; T09957.
DR RefSeq; NP_008455.1; NC_001960.1.
DR AlphaFoldDB; Q9ZZM3; -.
DR SMR; Q9ZZM3; -.
DR STRING; 8030.ENSSSAP00000000012; -.
DR GeneID; 808309; -.
DR KEGG; sasa:808309; -.
DR CTD; 4540; -.
DR OMA; GVGIMSF; -.
DR OrthoDB; 526738at2759; -.
DR Proteomes; UP000087266; Mitochondrion MT.
DR Bgee; ENSSSAG00000000033; Expressed in zone of skin and 16 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..612
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118146"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 463..483
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 494..514
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 591..611
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 177
FT /note="V -> M (in Ref. 2; AAF61388)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 612 AA; 67610 MW; 58C99457196E405E CRC64;
MHPTTLILSS TLLMIFALLL YPLITTLNPT PQQENWALTH VKTAIKMAFL VSLLPLFIFL
DQGTETIVTN WQWMNTTTFD INLSFKFDHY SIIFTPIALY VTWSILEFAS WYMHADPNMN
RFFKYLLLFL IAMIILVTAN NMFQLFIGWE GVGIMSFLLI GWWYGRADAN TAAMQAVIYN
RVGDIGLILS MAWFATNLNS WEIQQMFASS KELDLTLPLM GLILAATGKS AQFGLHPWLP
SAMEGPTPVS ALLHSSTMVV AGIFLLIRLH PLMENNQTAL TTCLCLGALT TLFTATCALT
QNDIKKIVAF STSSQLGLMM VTIGLNQPQL AFLHICTHAF FKAMLFLCSG SIIHSLNDEQ
DIRKMGGMHN LTPFTSSCLT IGSLALTGTP FLAGFFSKDA IIEALNTSHL NAWALTLTLL
ATSFTAVYSL RVVFFVSMGH PRFTATAPIN ENNPSVINPI KRLAWGSIIA GLLITSNFLP
SKTPIMTMPL PLKLAALLVT ISGLLIALEL ASLTNKQFKT TPNLITHNFS NMLGFFPAII
HRLAPKLNLT LGQTIASQMV DQTWFEKIGP KGVVSTHLPM VTTTSNIQQG MIKTYLTLFF
LSTALAVLLT LT
