NU5M_SCHCO
ID NU5M_SCHCO Reviewed; 686 AA.
AC P50368;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=ND5; Synonyms=NAD5;
OS Schizophyllum commune (Split gill fungus).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX NCBI_TaxID=5334;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 44201 / CBS 340.81 / UVM 4-40 / 4-40;
RA Paquin B., Roewer I., Wang Z., Lang B.F.;
RT "A robust fungal phylogeny using the mitochondrially encoded nad5 protein
RT sequence.";
RL Can. J. Bot. 73:S180-S185(1995).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; U17012; AAA99063.1; -; Genomic_DNA.
DR PIR; T14203; T14203.
DR AlphaFoldDB; P50368; -.
DR SMR; P50368; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..686
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118147"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 432..452
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 472..492
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 526..546
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 635..655
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 665..685
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 686 AA; 76186 MW; 1C12988106DF793E CRC64;
MNLIILFLPF VGAFISGFLG RFVGTTGAQI LTCACILTSA LLSLYYWLSI NELIIGLFSF
EGDQVYFTDW NFLSNNTFIN LGTWVDSEYI KISWEFTFNE ITLPFLFTVL FISFLIHLFS
VNYMANDPHI QRFFSYLSLF TFFMAILVTG ANYFVLFVGW EGIGVVSYLL INFWFTRIQA
NKAAILAFNT NRIGDMALSI AYFVMLPAFG SADFSTVFSL PAYINQTTIT IIGFLLLVGA
MAKSSQIPLH NWLPGSMEGP TPVSALIHAA TLVTAGSYLL IRSSPILEYA PTVLLVITII
GASTAFFAAT CGLVQNDIKR IIAFSTISQL GYMVMAIGLS QYNVALAHTL FHAYFKALLF
LGAGSVIHAF GDIQDVRKMG GLINFLPFTY AVMLVGTLSL LATPFLTGFY SKDLIIELAY
GQYSFSGTYA YILGSVTAGL TAFYSFRLIS LVFLTKPNGN KQNYLNSHEA SITVIIPLAV
LAIFSIFFGY VTSDLFVGIG SDFFANTIFI HPNNISLVEA EFSMSLIFKL LPTIFSLAGT
LFALYLYNYN PHFIDSLVEN NLGKKVYGFL NGKYYFDVIY NNYIISKGLQ FGYNISKEID
RGVIELIGPY GMSNVLYSTS ANIAKLDTGI ITTYALYITL GLLSLLFIVF APMLVNTTIN
DEFRLIILFI FTLIVNSAYL NKKLSK
