NU5M_SCYCA
ID NU5M_SCYCA Reviewed; 609 AA.
AC O79411;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Scyliorhinus canicula (Small-spotted catshark) (Squalus canicula).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=7830;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Muscle;
RX PubMed=9725850; DOI=10.1093/genetics/150.1.331;
RA Delarbre C., Spruyt N., Delmarre C., Gallut C., Barriel V., Janvier P.,
RA Laudet V., Gachelin G.;
RT "The complete nucleotide sequence of the mitochondrial DNA of the dogfish,
RT Scyliorhinus canicula.";
RL Genetics 150:331-344(1998).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; Y16067; CAA76029.1; -; Genomic_DNA.
DR PIR; T11310; T11310.
DR RefSeq; NP_007624.1; NC_001950.1.
DR AlphaFoldDB; O79411; -.
DR SMR; O79411; -.
DR GeneID; 808303; -.
DR CTD; 4540; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..609
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118148"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 485..505
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 589..609
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 609 AA; 68410 MW; 5FB1210340C206D4 CRC64;
MNTIFNSSFL LIFITLMIPL VTSLSPKKLN PSPSSFYVKT AVKISFFISL IPLFIFLDQG
LESIVTNWNW MNMGPFNINM SFKFDLYSIM FTPVALYVTW SILEFALWYM HLDPNINRFF
KYLLLFLISM IILVTANNMF QLFIGWEGVG IMSFLLIGWW YSRTDANTAA LQAVIYNRIG
DIGLILSMAW LAMNLNSWEI QQIFILSKDK DLTLPLLGLV LAAAGKSAQF GLHPWLPSAM
EGPTPVSALL HSSTMVVAGI FLLIRLHPLI QDNQFILTTC LCLGAITTLF TATCALTQND
IKKIIAFSTS SQLGLMMVTI GLNQPQLAFL HICTHAFFKA MLFLCSGSII HSLNDEQDIR
KMGGLHKLLP FTSSSLTVGS LALTGMPFLS GFFSKDAIIE AMNTSHLNAW ALILTLVATS
FTAIYSLRLI FFTLMKFPRF NSFSPINENN PMVINPLKRL AYGSIIAGLI ITSNLPPAKT
QIMTMSPLLK LSALLVTILG LLLALELTNL THSQFKIYPT FPYHHFSNML GYFPPIIHRL
LPKINLNWAQ HISTHLIDQT WNEKIGPKST LIQQIPLIKL STHPQQGYIK TYLTLLFLTL
TLIILVVFI
