NU5M_SHEEP
ID NU5M_SHEEP Reviewed; 606 AA.
AC O78756;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Ovis aries (Sheep).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Merinolandschaf {ECO:0000312|Proteomes:UP000002356}; TISSUE=Liver;
RX PubMed=9767689; DOI=10.1007/pl00006401;
RA Hiendleder S., Lewalski H., Wassmuth R., Janke A.;
RT "The complete mitochondrial DNA sequence of the domestic sheep (Ovis aries)
RT and comparison with the other major ovine haplotype.";
RL J. Mol. Evol. 47:441-448(1998).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03915}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03915};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03920}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; AF010406; AAD10105.1; -; Genomic_DNA.
DR PIR; T11060; T11060.
DR RefSeq; NP_008416.1; NC_001941.1.
DR PDB; 5LNK; EM; 3.90 A; L=1-599.
DR PDB; 6Q9B; EM; 3.90 A; D5=1-606.
DR PDB; 6QA9; EM; 4.10 A; D5=1-606.
DR PDB; 6QBX; EM; 4.20 A; D5=1-606.
DR PDB; 6QC2; EM; 4.20 A; D5=1-606.
DR PDB; 6QC3; EM; 4.20 A; D5=1-606.
DR PDB; 6QC4; EM; 4.60 A; D5=1-606.
DR PDB; 6QC5; EM; 4.30 A; D5=1-606.
DR PDB; 6QC6; EM; 4.10 A; D5=1-606.
DR PDB; 6QC7; EM; 4.40 A; D5=1-606.
DR PDB; 6QC8; EM; 4.20 A; D5=1-606.
DR PDB; 6QC9; EM; 5.70 A; D5=1-606.
DR PDB; 6QCA; EM; 6.20 A; D5=1-606.
DR PDB; 6QCF; EM; 6.50 A; D5=1-606.
DR PDB; 6ZKA; EM; 2.50 A; L=1-606.
DR PDB; 6ZKB; EM; 2.90 A; L=1-606.
DR PDB; 6ZKC; EM; 3.10 A; L=1-606.
DR PDB; 6ZKD; EM; 2.70 A; L=1-606.
DR PDB; 6ZKE; EM; 2.60 A; L=1-606.
DR PDB; 6ZKF; EM; 2.80 A; L=1-606.
DR PDB; 6ZKG; EM; 3.40 A; L=1-606.
DR PDB; 6ZKH; EM; 3.00 A; L=1-606.
DR PDB; 6ZKI; EM; 2.80 A; L=1-606.
DR PDB; 6ZKJ; EM; 3.00 A; L=1-606.
DR PDB; 6ZKK; EM; 3.70 A; L=1-606.
DR PDB; 6ZKL; EM; 3.10 A; L=1-606.
DR PDB; 6ZKM; EM; 2.80 A; L=1-606.
DR PDB; 6ZKN; EM; 2.90 A; L=1-606.
DR PDB; 6ZKO; EM; 3.80 A; L=1-606.
DR PDB; 6ZKP; EM; 3.20 A; L=1-606.
DR PDB; 6ZKQ; EM; 3.30 A; L=1-606.
DR PDB; 6ZKR; EM; 3.50 A; L=1-606.
DR PDB; 6ZKS; EM; 3.10 A; L=1-606.
DR PDB; 6ZKT; EM; 2.80 A; L=1-606.
DR PDB; 6ZKU; EM; 3.00 A; L=1-606.
DR PDB; 6ZKV; EM; 2.90 A; L=1-606.
DR PDBsum; 5LNK; -.
DR PDBsum; 6Q9B; -.
DR PDBsum; 6QA9; -.
DR PDBsum; 6QBX; -.
DR PDBsum; 6QC2; -.
DR PDBsum; 6QC3; -.
DR PDBsum; 6QC4; -.
DR PDBsum; 6QC5; -.
DR PDBsum; 6QC6; -.
DR PDBsum; 6QC7; -.
DR PDBsum; 6QC8; -.
DR PDBsum; 6QC9; -.
DR PDBsum; 6QCA; -.
DR PDBsum; 6QCF; -.
DR PDBsum; 6ZKA; -.
DR PDBsum; 6ZKB; -.
DR PDBsum; 6ZKC; -.
DR PDBsum; 6ZKD; -.
DR PDBsum; 6ZKE; -.
DR PDBsum; 6ZKF; -.
DR PDBsum; 6ZKG; -.
DR PDBsum; 6ZKH; -.
DR PDBsum; 6ZKI; -.
DR PDBsum; 6ZKJ; -.
DR PDBsum; 6ZKK; -.
DR PDBsum; 6ZKL; -.
DR PDBsum; 6ZKM; -.
DR PDBsum; 6ZKN; -.
DR PDBsum; 6ZKO; -.
DR PDBsum; 6ZKP; -.
DR PDBsum; 6ZKQ; -.
DR PDBsum; 6ZKR; -.
DR PDBsum; 6ZKS; -.
DR PDBsum; 6ZKT; -.
DR PDBsum; 6ZKU; -.
DR PDBsum; 6ZKV; -.
DR AlphaFoldDB; O78756; -.
DR SMR; O78756; -.
DR STRING; 9940.ENSOARP00000000011; -.
DR PRIDE; O78756; -.
DR Ensembl; ENSOART00000000032; ENSOARP00000000011; ENSOARG00000000032.
DR Ensembl; ENSOART00020000031; ENSOARP00020000010; ENSOARG00020000031.
DR GeneID; 808258; -.
DR KEGG; oas:808258; -.
DR CTD; 4540; -.
DR eggNOG; KOG4668; Eukaryota.
DR HOGENOM; CLU_007100_6_0_1; -.
DR OMA; GVGIMSF; -.
DR OrthoDB; 526738at2759; -.
DR Proteomes; UP000002356; Mitochondrion.
DR Bgee; ENSOARG00000000032; Expressed in cardiac muscle tissue of left auricle and 55 other tissues.
DR ExpressionAtlas; O78756; baseline and differential.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; NAD; Reference proteome; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..606
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118149"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 485..505
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 582..602
FT /note="Helical"
FT /evidence="ECO:0000255"
FT HELIX 2..23
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 32..57
FT /evidence="ECO:0007829|PDB:6ZKA"
FT STRAND 61..71
FT /evidence="ECO:0007829|PDB:6ZKA"
FT STRAND 74..83
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 84..107
FT /evidence="ECO:0007829|PDB:6ZKA"
FT TURN 108..110
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 114..133
FT /evidence="ECO:0007829|PDB:6ZKA"
FT STRAND 134..136
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 137..155
FT /evidence="ECO:0007829|PDB:6ZKA"
FT STRAND 156..158
FT /evidence="ECO:0007829|PDB:6ZKV"
FT HELIX 162..193
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 198..204
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 210..223
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 232..235
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 236..238
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 241..246
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 247..251
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 255..262
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 264..267
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 271..291
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 292..294
FT /evidence="ECO:0007829|PDB:6ZKE"
FT HELIX 298..318
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 322..349
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 356..358
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 362..365
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 367..380
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 389..400
FT /evidence="ECO:0007829|PDB:6ZKA"
FT STRAND 401..404
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 406..430
FT /evidence="ECO:0007829|PDB:6ZKA"
FT STRAND 432..434
FT /evidence="ECO:0007829|PDB:6ZKA"
FT STRAND 439..441
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 448..471
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 484..487
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 489..506
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 507..509
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 518..524
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 526..528
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 529..546
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 547..556
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 557..561
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 563..577
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 584..600
FT /evidence="ECO:0007829|PDB:6ZKA"
SQ SEQUENCE 606 AA; 68367 MW; 2980FA8510882703 CRC64;
MNLFSSLTLV TLILLTMPIA AINFNTHKFT NYPLYVKTTI SCAFITSMIP TMMFIHTGQE
MIISNWHWLT IQTLKLSLSF KMDFFSMMFV PVALFVTWSI MEFSMWYMHS DPNINQFFKY
LLLFLITMLI LVTANNLFQL FIGWEGVGIM SFLLIGWWYG RTDANTAALQ AILYNRIGDI
GFILAMAWFL INLNTWDLQQ IFMLNPNDSN LPLMGLILAA TGKSAQFGLH PWLPSAMEGP
TPVSALLHSS TMVVAGIFLL IRFYPLTENN KFGQSIMLCL GAMTTLFTAM CALTQNDIKK
IIAFSTSSQL GLMMVTIGIN QPHLAFLHIC THAFFKAMLF MCSGSIIHSL NDEQDIRKMG
GLFKAMPFTT TALIIGSLAL TGMPFLTGFY SKDLIIESAN TSYTNAWALL MTLVATSFTA
IYSTRIIFFA LLGQPRFPTL ININENNPFL INSIKRLLIG SLFAGFIISN NIPPMTIPQM
TMPHYLKMTA LTVTILGFIL ALEISNTTHY LKFNYPSNTF KFSNLLGYYP TIMHRLTPYM
NLTMSQKSAS SLLDLIWLET ILPKTISLAQ MKMSTTITSQ KGLIKLYFLS FLITILISTT
LLNFHE
