NU5M_STRCA
ID NU5M_STRCA Reviewed; 605 AA.
AC Q35813;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 2.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=MT-ND5; Synonyms=MTND5, NADH5, ND5;
OS Struthio camelus (Common ostrich).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC Struthio.
OX NCBI_TaxID=8801;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9214748; DOI=10.1093/oxfordjournals.molbev.a025815;
RA Harlid A., Janke A., Arnason U.;
RT "The mtDNA sequence of the ostrich and the divergence between paleognathous
RT and neognathous birds.";
RL Mol. Biol. Evol. 14:754-761(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11370967; DOI=10.1098/rspb.2001.1587;
RA Haddrath O., Baker A.J.;
RT "Complete mitochondrial DNA genome sequences of extinct birds: ratite
RT phylogenetics and the vicariance biogeography hypothesis.";
RL Proc. R. Soc. B 268:939-945(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-48.
RX PubMed=7476123; DOI=10.1093/oxfordjournals.molbev.a040254;
RA Kumazawa Y., Nishida M.;
RT "Variations in mitochondrial tRNA gene organization of reptiles as
RT phylogenetic markers.";
RL Mol. Biol. Evol. 12:759-772(1995).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; Y12025; CAA72754.1; -; Genomic_DNA.
DR EMBL; AF338715; AAK53356.1; -; Genomic_DNA.
DR EMBL; D38186; BAA07379.1; -; Genomic_DNA.
DR PIR; C90613; C90613.
DR PIR; T11529; T11529.
DR RefSeq; NP_115451.1; NC_002785.1.
DR AlphaFoldDB; Q35813; -.
DR SMR; Q35813; -.
DR GeneID; 803275; -.
DR CTD; 4540; -.
DR OrthoDB; 526738at2759; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..605
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118152"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 371..391
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 483..503
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 583..603
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 605 AA; 66436 MW; 36C37BF71D95C68F CRC64;
METTLLFNTS LLLTLMILLT PILLPLLSTK LQNTPLIITT TVKMAFFTSI IPTTIFIYSG
TEAIISHWYW SFTPNLKIPL SFKMDQYSML FLPVALFVTW SILQFAMWYM ASEPHVTKFF
IYLLMFLIAM LTLTIANNMF MLFIGWEGVG IMSFLLISWW HGRAEANTAA LQAVIYNRIG
DVGLILSMAW LASTLNTWEI QQISYESQTP ILPLLGLILA ATGKSAQFGL HPWLPAAMEG
PTPVSALLHS STMVVAGIFL LVRIHPLLAN NQTALTTCLC LGALSTLFAA TCALTQNDIK
KIIAFSTSSQ LGLMMVTIGL NLPQLAFLHI STHAFFKAML FLCSGSIIHS LAGEQDIRKM
GGLQKLLPTT TSCLTIGNLA LMGTPFLAGF YSKDLIIESL NNSYLNAWAL LLTLLATSFT
ATYSLRMTLM VQSGFSRIPP ITPINENTPL VINPITRLAL GSIMAGLLIT SNILPTKTPP
MTMPTIMKTA AIVVTILGIL LALELSNMTH NLTAPKQNIY SNFSTTLGYF NPLAHRLSSM
KLLNNGQKIA SHLIDLSWYK KMGPEGLADL QLMAAKTSTP LHTGLIKTYL GTFALSILIL
LTLTH
