NU5M_STRPU
ID NU5M_STRPU Reviewed; 637 AA.
AC P15552; Q35902;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=ND5;
OS Strongylocentrotus purpuratus (Purple sea urchin).
OG Mitochondrion.
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC Strongylocentrotus.
OX NCBI_TaxID=7668;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3172215; DOI=10.1016/0022-2836(88)90452-4;
RA Jacobs H.T., Elliott D.J., Math V.B., Farquharson A.;
RT "Nucleotide sequence and gene organization of sea urchin mitochondrial
RT DNA.";
RL J. Mol. Biol. 202:185-217(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-131.
RX PubMed=2488275;
RA Thomas W.K., Maa J., Wilson A.C.;
RT "Shifting constraints on tRNA genes during mitochondrial DNA evolution in
RT animals.";
RL New Biol. 1:93-100(1989).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; X12631; CAA31160.1; -; Genomic_DNA.
DR EMBL; M27669; AAA32083.2; -; Genomic_DNA.
DR PIR; S01509; S01509.
DR RefSeq; NP_006975.1; NC_001453.1.
DR AlphaFoldDB; P15552; -.
DR SMR; P15552; -.
DR EnsemblMetazoa; GeneID_2652725_df_mr; NP_006975; GeneID_2652725.
DR GeneID; 2652725; -.
DR KEGG; spu:2652725; -.
DR CTD; 4540; -.
DR InParanoid; P15552; -.
DR OMA; LLISWWT; -.
DR OrthoDB; 526738at2759; -.
DR PhylomeDB; P15552; -.
DR Proteomes; UP000007110; Unassembled WGS sequence.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0003954; F:NADH dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..637
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118154"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 435..455
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 492..512
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 520..540
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 557..577
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 617..637
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 73
FT /note="V -> A (in Ref. 2; AAA32083)"
FT /evidence="ECO:0000305"
FT CONFLICT 86..92
FT /note="CNNSIQS -> VNTGFSE (in Ref. 2; AAA32083)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 637 AA; 68558 MW; C62EF3DA33B3803E CRC64;
MVISPSLIIS SLNLGILTIL LGSIFFFSKS YFSKGNVNFP LIKTTSACLS VNNDKEETIE
YNSGPFAMAI LKVLAFLSVL SLLVTCNNSI QSINITLSLW LSNTPLNISL NFIYDQYFLV
FLSVALIVTW SIMEFSFYYM TEDPNSSAFF RLLTIFLLNM LILTCSNSLF LIFLGWEGGG
FLSFLLISWW TTRNDASSSA LEAVITNRIG NIGLITFMAL SALNFNSSNL TNILSSNENL
TPLLPFLLFG LILAAAGKSA QFGLHPWLPA LLEGPTPVSA LLHSSTMVVA GVFLLVRTSE
LFSSPLITHS LVLILGGTTA LFAASTAIAQ HDIKKIIAYS TTSQLGLMVT AIGIGQPALA
FFHICTHAFF KAMLFLCSGS VIHSLSDEQD LRKMGGLSKL LPVTSSCLIL GSLALMAPLL
AGFYSKDLIL EATSASVLNL LGIVLSIVAT MLTAVYSFRI IFFCFSLSPS CSSPFSHSEE
NFNLNNALLR LATGTIASGW FFSNLLFAPP SFNVTSLAKG TPLIVPIIGV AALFMSLISS
TSNSIGSNAH SATTSQWFFV DAVHLSIITM SLALSFFSSR TLDRGWQENI GPQGIAPTST
ALSKISQAGQ IGLIKRYILS SMASVLVILA LSLLILS
