NU5M_TALMA
ID NU5M_TALMA Reviewed; 658 AA.
AC Q6V9D9;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
GN Name=nad5;
OS Talaromyces marneffei (Penicillium marneffei).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=37727;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MP1;
RX PubMed=14675758; DOI=10.1016/s0014-5793(03)01307-3;
RA Woo P.C.Y., Zhen H., Cai J.J., Yu J., Lau S.K.P., Wang J., Teng J.L.L.,
RA Wong S.S.Y., Tse R.H., Chen R., Yang H., Liu B., Yuen K.-Y.;
RT "The mitochondrial genome of the thermal dimorphic fungus Penicillium
RT marneffei is more closely related to those of molds than yeasts.";
RL FEBS Lett. 555:469-477(2003).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; AY347307; AAQ54911.1; -; Genomic_DNA.
DR RefSeq; NP_943710.1; NC_005256.1.
DR AlphaFoldDB; Q6V9D9; -.
DR SMR; Q6V9D9; -.
DR GeneID; 2657820; -.
DR VEuPathDB; FungiDB:PMAA_m0550; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..658
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118129"
FT TRANSMEM 4..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 329..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..431
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 452..471
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 505..527
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 607..629
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 639..656
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 658 AA; 73418 MW; 58147153769CBC7C CRC64;
MYLTLIVLPL LGSISSGFFG RKIGVSGSHI ITCSSVILTT LLALLAFIEV GINNIPVTID
VARWIDAEAL NVMWSFKFDS LTVSMLIPVL IVSSLVHIYS ISYMSHDPHN QRFFSYLSLF
TFMMIILVTG NNYLLMFVGW EGVGICSYLL INFWFTRIAA NQSSISALLT NRVGDCFLTI
GIFAMLWSFG NIDYNLIFSL APYYNENIIT MIGICLVIGA TAKSSQVGLH IWLPQAMEGP
TPVSALIHAA TMVTAGVYLL MRSSPLIEYS STVLIICLWL GAITTVFSSL IGLFQQDIKK
VIAYSTMSQL GMMVIGIGLS SYNIALFHLV NHAFYKALLF LGAGAVIHSV ADNQDFRKYG
GLRPFLPLTY SVMLIASLSL VAVPFMTGFY SKDLILESAY GQFYLSGTIV YFIATIGAMF
TTLYSAKVLY LTFLTNPNGP LNNYKYAHEG DLFLNIPLII LAVFSIFFGF LTKDIFIGLG
TGFFSDNSLF IHPNHEILLD TEFAVPVLFK LLPFFFTISL SILSILYSEF TPNLLINFKF
STLGYNIFSF FNQRFYIELL YNKYIVENIL TLGGQTTKSL DKGSVEYLGP YGLEKGLLNL
SNSINNLSTG VVTTYALYIL MGLMFYISTL YFFNWDSNLL ILIIFSLFVI LNNKLLQK
