NU5M_TRIRU
ID NU5M_TRIRU Reviewed; 653 AA.
AC Q01561; Q9T9N1;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 23-APR-2003, sequence version 2.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=ND5; Synonyms=NADH5;
OS Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=5551;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=IP 1817.89;
RX PubMed=10022946; DOI=10.1007/s002940050429;
RA de Bievre C., Dujon B.;
RT "Organisation of the mitochondrial genome of Trichophyton rubrum III. DNA
RT sequence analysis of the NADH dehydrogenase subunits 1, 2, 3, 4, 5 and the
RT cytochrome b gene.";
RL Curr. Genet. 35:30-35(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-337.
RC STRAIN=IP 1817.89;
RX PubMed=1326416; DOI=10.1007/bf00351730;
RA de Bievre C., Dujon B.;
RT "Mitochondrial DNA sequence analysis of the cytochrome oxidase subunit I
RT and II genes, the ATPase9 gene, the NADH dehydrogenase ND4L and ND5 gene
RT complex, and the glutaminyl, methionyl and arginyl tRNA genes from
RT Trichophyton rubrum.";
RL Curr. Genet. 22:229-234(1992).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; Y18476; CAA77185.1; -; Genomic_DNA.
DR EMBL; X65223; CAA46329.1; -; Genomic_DNA.
DR PIR; S26950; S26950.
DR PIR; T14241; T14241.
DR AlphaFoldDB; Q01561; -.
DR SMR; Q01561; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..653
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118158"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 452..472
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 511..531
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 610..630
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 631..651
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 653 AA; 73457 MW; 58207B990F568E14 CRC64;
MYLVIIFLPL LGSIISGFFG RKIGVQGAQL ITSSFIIITT MLAIFNFFEV GYNNIPLEIN
LFRWIDSESI NILWGFYFDS LTVSMLIPVL IVSSLVHIYS IGYMSHDPHN QRFFSYLSLF
TFMMIILVTA NNYLLMFLGV EGVGVCSYLL VNFWFTRIAA NQSSISAFLT NRVGDCFLTI
GMFIIIWSFG NLDYSTVFSL APYFNQEFIT LIGICLLIGA MAKSSQIGLH VWLPQAMEGP
TPVSALIHAA TMVTAGVYLL MRSSPLIEYS STVLILCLWL GAITTIFSSI IGLFQQDIKK
VIAYSTMSQL GMMVIAIGLS SYNLALFHLV NHAFYKALLF LGAGAVIHSV SDNQDFRKYG
GLKPFLPLAY SIMLIASLSL VAIPFMSGFY SKDFILESAY GQFYISSTLV YFIATIGAMF
TTLYSVKVLY LTFLTNPNGP LNNYKNVDQG NIFINLPLII LAIFSIFFGY LTKDVFIGLG
TSFFIDNRYF IHPSHEIMLD TEFALPTLFK LLPLFFTITL SIIGIMFSEF FGNLLIKFKF
TNLGYNIFSL FNQRFLIEFF YNNYITNFVL KLGGQTTKVL YKGSVELLGP YGLEKRLLNL
SKNIGSLSTG VITSYALYIL IGLIFYVFLL YLNIDNNILL LLLFGIFSTI NKK
