NU5M_WHEAT
ID NU5M_WHEAT Reviewed; 670 AA.
AC Q37680;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=ND5; Synonyms=NAD5;
OS Triticum aestivum (Wheat).
OG Mitochondrion.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1726722; DOI=10.1105/tpc.3.12.1363;
RA de Souza A.P., Jubier M.-F., Delcher E., Lancelin D., Lejeune B.;
RT "A trans-splicing model for the expression of the tripartite nad5 gene in
RT wheat and maize mitochondria.";
RL Plant Cell 3:1363-1378(1991).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; M74159; AAA32142.2; -; Genomic_DNA.
DR EMBL; M74157; AAA32142.2; JOINED; Genomic_DNA.
DR EMBL; M74158; AAA32142.2; JOINED; Genomic_DNA.
DR PIR; JQ1447; JQ1447.
DR AlphaFoldDB; Q37680; -.
DR SMR; Q37680; -.
DR STRING; 4565.EPlTAEP00000010100; -.
DR eggNOG; KOG4668; Eukaryota.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009536; C:plastid; IEA:UniProt.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..670
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118160"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 425..445
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 461..481
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 618..638
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 670 AA; 74421 MW; E845F568B5FEFE68 CRC64;
MYLLIVFLPL LGSSVAGFFG RFLGSEGTAI MTTTCVSFSS ILSLIAFYEV ALGASACYLR
IAPWISSEMF DASWGFLFDS LTVVMLIVVT FISSLVHLYS ISYMSEDPHS PRFMCYLSIF
TFFMLMLVTG DNFLQLFLGW EGVGLASYLL IHFWFTRLQA DKAAIKAMLV NRVGDFGLAL
GIFGCFTLFQ TVDFSTIFAC ASAPRNEWIF CNMRLNAITL ICILLFIGAV GKSAQIGLHT
WLPDAMEGPT PVSALIHAAT MVTAGVFMIA RCSPLFEYSP TALIVITFAG AMTSFLAATT
GILQNDLKRV IAYSTCSQLG YMIFACGISN YSVSVFHLMN HAFFKALLFL SAGSVIHAMS
DEQDMRKMGG LASSFPLTYA MMLMGSLSLI GFPFLTGFYS KDVILELAYT KYTISGNFAF
WLGSVSVLFT SYYSFRLLFL TFLVPTNSFG RDRLRCHDAP IPMAIPLILL ALGSLFVGYL
AKDMMIGLGT NFWANSPFVL PKNEILAESE FAAPTITKLI PILFSTSGAS LAYNVNLVAD
QFQRAFQTST FCNRLYSFFN KRWFFDQVLN DFLVRSFLRF GYSVSFEALD KGAIEILGPY
GISYTFRRLA ERISQLQSGS VYHYAFAMLL GSTPFVTFSR MWDSLSSWVD SRSSFILLVS
SFLINKSSQE
