NU5M_WICCA
ID NU5M_WICCA Reviewed; 644 AA.
AC Q37024;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 2.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
GN Name=ND5;
OS Wickerhamomyces canadensis (Yeast) (Pichia canadensis).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Wickerhamomyces.
OX NCBI_TaxID=1156965;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=21;
RX PubMed=8202091; DOI=10.1007/bf00280478;
RA Okamoto K., Sekito T., Yoshida K.;
RT "The mitochondrial genome of yeast Hansenula wingei encodes NADH
RT dehydrogenase subunit genes ND4L and ND5.";
RL Mol. Gen. Genet. 243:473-476(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=21;
RX PubMed=8536312; DOI=10.1007/bf00311880;
RA Sekito T., Okamoto K., Kitano H., Yoshida K.;
RT "The complete mitochondrial DNA sequence of Hansenula wingei reveals new
RT characteristics of yeast mitochondria.";
RL Curr. Genet. 28:39-53(1995).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; D16253; BAA03779.2; -; Genomic_DNA.
DR EMBL; D31785; BAA06571.2; -; Genomic_DNA.
DR PIR; S44478; S44478.
DR RefSeq; NP_038216.1; NC_001762.1.
DR AlphaFoldDB; Q37024; -.
DR SMR; Q37024; -.
DR GeneID; 800543; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..644
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118133"
FT TRANSMEM 4..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..349
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..383
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..420
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 466..488
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 517..539
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 546..568
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 594..616
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 623..642
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 644 AA; 74560 MW; C1E306720DB4816A CRC64;
MILFITLPLL NVIISGLLSR YIGVNNIKRL NIINLFIILI LLIYYYINII KTDNEYTLKI
IEWINIEYLN INYSFNLDLL SITMLIPIIL ISLIVNIFAW EYMKDDSHNP RFYTYLALFT
LFMIILVLGD NYLILFLGWE YIGIASFLLI GFWYNNIDNI KSSLNALFIN KIGDIFFIIA
LIYLIYIYKS LNYSLIFSLV SYINIDINNI IILCLVIAAS AKSAQFGLHN WLIWAMAGPT
PVSVLLHAAT LVIAGIYLLM RSSPILENCP NILLFNLWLG AITSLISGLI AINSNDIKRI
IALSTMSQLG IMFISIGLSS YNLTLYHVLC HSLYKALLFI CAGTIIHSLN NELQDIRFMG
GLLIYMPITY ICMLIGSLSL MGLPSLTGYY SKDIIIESSI GIFTISGLII YWLVVLSSLL
TNIYILKLIY YSFINIPQLN KYIYNSLSLN NTYSLPFNFK FNFDKSWMAI ICMIILSIGS
LFIGYLLQDI YLGQGNSING LFIYPNNLNL IETHFAINIY YKWIPIFNIF ISILLIIYLY
EFNYKLLYIY NNPLFYNFYI LFNTRFLFDQ ILNNYIIRYT LYLSKSLNSL LDKGFLYTLG
PNGLNYLLNL LSFNIIKFNT HLFNHYLIYI SFSLLLFIYL QFDL
