NU5M_XENLA
ID NU5M_XENLA Reviewed; 604 AA.
AC P03922;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03915};
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=mt-nd5; Synonyms=mtnd5, nadh5, nd5;
OS Xenopus laevis (African clawed frog).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=4019494; DOI=10.1016/s0021-9258(17)39303-1;
RA Roe B.A., Ma D.-P., Wilson R.K., Wong J.F.-H.;
RT "The complete nucleotide sequence of the Xenopus laevis mitochondrial
RT genome.";
RL J. Biol. Chem. 260:9759-9774(1985).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03915}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03915};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03920}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03920}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; M10217; AAA66468.1; -; Genomic_DNA.
DR PIR; A00452; QXXL5M.
DR RefSeq; NP_008144.1; NC_001573.1.
DR AlphaFoldDB; P03922; -.
DR SMR; P03922; -.
DR MaxQB; P03922; -.
DR GeneID; 2642078; -.
DR KEGG; xla:2642078; -.
DR CTD; 4540; -.
DR Xenbase; XB-GENE-6251967; nd5.L.
DR OrthoDB; 526738at2759; -.
DR Proteomes; UP000186698; Mitochondrion MT.
DR Bgee; 2642078; Expressed in gastrula and 19 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..604
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118161"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..332
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 371..391
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 458..478
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 483..503
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 584..604
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 604 AA; 67156 MW; 0C6115694B0FF1C4 CRC64;
MNFPLIFNSS MLITISILIL PILMSTFNMN IMNLHHLIKT SVKTAFLISI IPLIIFLDQG
LESITTNFHW MNINTFDINM SFKFDIYSSI FIPIALFVTW SILEFATWYM ASDPMISRFF
KYLLTFLVAM VILVTANNFF QFFIGWEGVG IMSFLLIGWW YARAEPNTAA LQAVIYNRVG
DIGLILSMAW VAMNLNSWEM QQVFMLNSDN LTLPLLGLIL AATGKSAQFG LHPWLPAAME
GPTPVSALLH SSTMVVAGIF LLIRISPMMN NNQTALTICL CLGAMTTLFT AACALTQNDI
KKIVAFSTSS QLGLMMVTIG LIFQLAFFHI CNNAFFKVYY FFCSGQYSSC LNDEQDIRKM
GGLQNSLPIT TSCLTIGSLA LTGTPFLAGF FSKDAIIEAL NTSQTNTWAL TLTLIATSFT
AIYSFRVIFF ASMGHPRSNP LSPINENNKT VINPIKRLAW GSIVAGLLIA SNMLPINSPI
MTMPTLAKQA AIIVSVTGLI IAMDLSKLTT YINQESKTNI HSFSNLLGFF PTIIHRMMPK
TNLNLAQNIA THLIDLSWYE KSGPQGMVNQ QLPMIKTTTN IQQGLIKTYL TLFLMTSAII
ITLF
