NU5M_YARLI
ID NU5M_YARLI Reviewed; 655 AA.
AC Q9B6D3;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=ND5;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20460 / W29 / CBS 7504 / IFP29;
RX DOI=10.1002/cfg.72;
RA Kerscher S., Durstewitz G., Casaregola S., Gaillardin C., Brandt U.;
RT "The complete mitochondrial genome of Yarrowia lipolytica.";
RL Comp. Funct. Genomics 2:80-90(2001).
RN [2]
RP SUBUNIT.
RX PubMed=15282186; DOI=10.1016/j.bbabio.2004.04.019;
RA Abdrakhmanova A., Zickermann V., Bostina M., Radermacher M., Schagger H.,
RA Kerscher S., Brandt U.;
RT "Subunit composition of mitochondrial complex I from the yeast Yarrowia
RT lipolytica.";
RL Biochim. Biophys. Acta 1658:148-156(2004).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBUNIT: Complex I is composed of 37 different subunits.
CC {ECO:0000269|PubMed:15282186}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR EMBL; AJ307410; CAC28107.2; -; Genomic_DNA.
DR RefSeq; NP_075440.2; NC_002659.1.
DR PDB; 6GCS; EM; 4.32 A; 5=1-655.
DR PDB; 6H8K; X-ray; 3.79 A; 5=73-653.
DR PDB; 6RFQ; EM; 3.30 A; 5=1-655.
DR PDB; 6RFR; EM; 3.20 A; 5=1-655.
DR PDB; 6RFS; EM; 4.04 A; 5=1-655.
DR PDB; 6Y79; EM; 3.20 A; 5=1-655.
DR PDB; 6YJ4; EM; 2.70 A; L=1-655.
DR PDBsum; 6GCS; -.
DR PDBsum; 6H8K; -.
DR PDBsum; 6RFQ; -.
DR PDBsum; 6RFR; -.
DR PDBsum; 6RFS; -.
DR PDBsum; 6Y79; -.
DR PDBsum; 6YJ4; -.
DR AlphaFoldDB; Q9B6D3; -.
DR SMR; Q9B6D3; -.
DR DIP; DIP-61441N; -.
DR IntAct; Q9B6D3; 2.
DR STRING; 284591.Q9B6D3; -.
DR GeneID; 802624; -.
DR KEGG; yli:YalifMp20; -.
DR InParanoid; Q9B6D3; -.
DR Proteomes; UP000001300; Mitochondrion.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0003954; F:NADH dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; PTHR42829; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR TIGRFAMs; TIGR01974; NDH_I_L; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; NAD; Reference proteome; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..655
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /id="PRO_0000118162"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..354
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 516..536
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 629..649
FT /note="Helical"
FT /evidence="ECO:0000255"
FT HELIX 4..55
FT /evidence="ECO:0007829|PDB:6YJ4"
FT STRAND 60..72
FT /evidence="ECO:0007829|PDB:6YJ4"
FT STRAND 74..81
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 83..106
FT /evidence="ECO:0007829|PDB:6YJ4"
FT TURN 107..109
FT /evidence="ECO:0007829|PDB:6RFR"
FT HELIX 113..132
FT /evidence="ECO:0007829|PDB:6YJ4"
FT STRAND 133..135
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 136..154
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 161..191
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 197..203
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 204..206
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 209..226
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 230..232
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 234..238
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 239..241
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 244..253
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 255..257
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 258..265
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 267..270
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 274..296
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 301..321
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 325..352
FT /evidence="ECO:0007829|PDB:6YJ4"
FT STRAND 353..355
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 360..362
FT /evidence="ECO:0007829|PDB:6YJ4"
FT TURN 367..369
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 371..382
FT /evidence="ECO:0007829|PDB:6YJ4"
FT TURN 383..386
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 391..405
FT /evidence="ECO:0007829|PDB:6YJ4"
FT STRAND 406..409
FT /evidence="ECO:0007829|PDB:6RFR"
FT HELIX 412..437
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 445..449
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 456..480
FT /evidence="ECO:0007829|PDB:6YJ4"
FT STRAND 482..484
FT /evidence="ECO:0007829|PDB:6RFQ"
FT HELIX 494..496
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 499..505
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 508..531
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 533..536
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 541..551
FT /evidence="ECO:0007829|PDB:6YJ4"
FT TURN 552..555
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 556..563
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 565..578
FT /evidence="ECO:0007829|PDB:6YJ4"
FT TURN 579..582
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 583..586
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 589..604
FT /evidence="ECO:0007829|PDB:6YJ4"
FT STRAND 605..607
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 613..637
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 642..654
FT /evidence="ECO:0007829|PDB:6YJ4"
SQ SEQUENCE 655 AA; 73705 MW; 53B2381DE9C85792 CRC64;
MYNAISLIII LPCISWLFPL FFGRQLGYVF VTRMTSTLII ITTLITYYYF YQLLGNNNPI
NLELFNYLNI DYLDINYNFE IDALTITMLL AITTISSMVH IYSIGYMETD PHQVRFFSLL
SMFTFWMIIL VTGSNYFVLF VGWEFIGVTS YLLISFWVTR LQAMKSALSA VLMNRFGDAF
FVLGLCVIAY VFGTLNYSTI FATAYLINTD LLVLIMLALF IAAMAKSAQF GLHNWLTLAM
EGPTPVSSLL HAATLVTAGI YLLLRSANIL EYTPTVLFII LWIGALTTLS AGLIAICSND
LKRIIALSTM SQLGMMTIAI GLSAYNLALF HLLGHAFFKA LLFMSAGSII HSILNESQDI
RTYGGLLSYL PYTYICITIA SLSLMAMPGL TGYYTKDIII ESTYGSYSIS NYVVYWIAYL
SAVLTCVYSM KILYLTFYSN PNNNTITYYN AHESNIYITL PMFILAIFAM FAGWILKDIY
LGVGTDFVGT HILPNNFSYF DTEFSITQFY KLLPLISAIL VSILIVVLNE FFAIVFNLNN
KYINTVYSIF NQKLVSDQIL NHFIIFKGLV TSGNIAHHVD KGSLYRLGPV GINRLLNKAS
YNVINLSSNT RSSLSMNSML ILITIVSLLL LVLVMNVNFI IVIPVLISIL YILFS
