NU6C_NOSS1
ID NU6C_NOSS1 Reviewed; 202 AA.
AC Q8Z075; Q9WWM5;
DT 01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=NAD(P)H-quinone oxidoreductase chain 6;
DE EC=7.1.1.-;
DE AltName: Full=NAD(P)H dehydrogenase I, chain 6;
DE AltName: Full=NDH-1, chain 6;
DE AltName: Full=NDH-G;
GN Name=ndhG; OrderedLocusNames=alr0225;
OS Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX NCBI_TaxID=103690;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Schiefer W., Happe T.;
RT "Isolation of the ndhAIGE gene cluster of Anabaena sp. PCC 7120.";
RL Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT "Complete genomic sequence of the filamentous nitrogen-fixing
RT cyanobacterium Anabaena sp. strain PCC 7120.";
RL DNA Res. 8:205-213(2001).
CC -!- FUNCTION: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-
CC sulfur (Fe-S) centers, to quinones in the respiratory chain. The
CC immediate electron acceptor for the enzyme in this species is believed
CC to be plastoquinone. Couples the redox reaction to proton translocation
CC (for every two electrons transferred, four hydrogen ions are
CC translocated across the cytoplasmic membrane), and thus conserves the
CC redox energy in a proton gradient (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n
CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:42608, Rhea:RHEA-COMP:9561,
CC Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62192;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n
CC H(+)(out) + NADP(+); Xref=Rhea:RHEA:42612, Rhea:RHEA-COMP:9561,
CC Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62192;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR EMBL; AJ242867; CAB44670.1; -; Genomic_DNA.
DR EMBL; BA000019; BAB77749.1; -; Genomic_DNA.
DR PIR; AI1834; AI1834.
DR RefSeq; WP_010994402.1; NZ_RSCN01000026.1.
DR AlphaFoldDB; Q8Z075; -.
DR SMR; Q8Z075; -.
DR STRING; 103690.17135203; -.
DR EnsemblBacteria; BAB77749; BAB77749; BAB77749.
DR KEGG; ana:alr0225; -.
DR eggNOG; COG0839; Bacteria.
DR OMA; MLVNKRE; -.
DR OrthoDB; 1683794at2; -.
DR Proteomes; UP000002483; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.120.1200; -; 1.
DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR Pfam; PF00499; Oxidored_q3; 1.
PE 3: Inferred from homology;
KW Membrane; NAD; NADP; Plastoquinone; Quinone; Reference proteome;
KW Translocase; Transmembrane; Transmembrane helix.
FT CHAIN 1..202
FT /note="NAD(P)H-quinone oxidoreductase chain 6"
FT /id="PRO_0000118365"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 11
FT /note="S -> P (in Ref. 1; CAB44670)"
FT /evidence="ECO:0000305"
FT CONFLICT 22
FT /note="T -> P (in Ref. 1; CAB44670)"
FT /evidence="ECO:0000305"
FT CONFLICT 177..181
FT /note="SGLPQ -> IWLTS (in Ref. 1; CAB44670)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 202 AA; 21406 MW; A677898543F0F7CC CRC64;
MNLAEGVQVV SFGILATMLI GTALGVVLAT SIVYSAFLLG GVFISIAGMY LLLNGDFVAA
AQVLVYVGAV NVLILFAIML VNKRQDFTPY PSAGIRKVLT AIVSVGLFAL LSTMVLATPW
AYSTTPKVGD GSIIVIGEHF FSDFLLPFEL ASVLLLMAMV GAIILARREY LPEVTPSGLP
QTVLTLPERP RELVGAGSET QE
