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NU6M_ANOGA
ID   NU6M_ANOGA              Reviewed;         174 AA.
AC   P34856;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 6;
GN   Name=mt:ND6; Synonyms=ND6;
OS   Anopheles gambiae (African malaria mosquito).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G3;
RX   PubMed=9087549; DOI=10.1111/j.1365-2583.1993.tb00131.x;
RA   Beard C.B., Hamm D.M., Collins F.H.;
RT   "The mitochondrial genome of the mosquito Anopheles gambiae: DNA sequence,
RT   genome organization, and comparisons with mitochondrial sequences of other
RT   insects.";
RL   Insect Mol. Biol. 2:103-124(1993).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR   EMBL; L20934; AAD12200.1; -; Genomic_DNA.
DR   PIR; T09811; T09811.
DR   RefSeq; NP_008079.1; NC_002084.1.
DR   AlphaFoldDB; P34856; -.
DR   STRING; 7165.AGAP028386-PA; -.
DR   GeneID; 1267423; -.
DR   KEGG; aga:ND6; -.
DR   CTD; 4541; -.
DR   VEuPathDB; VectorBase:AGAP028386; -.
DR   eggNOG; ENOG502TCTS; Eukaryota.
DR   HOGENOM; CLU_1548873_0_0_1; -.
DR   InParanoid; P34856; -.
DR   OMA; NMIHPLA; -.
DR   OrthoDB; 1617976at2759; -.
DR   Proteomes; UP000007062; Mitochondrion.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR   Pfam; PF00499; Oxidored_q3; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; NAD; Reference proteome;
KW   Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..174
FT                   /note="NADH-ubiquinone oxidoreductase chain 6"
FT                   /id="PRO_0000118239"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   174 AA;  20453 MW;  B04BECB7DB79C31F CRC64;
     MTKLIIMMMC LIMSFIFMQM KHPLSMGLML LIQTFLTCLI TGIYVKSFWF SYVLFLIFLG
     GMLILFIYVT SLSSNEMFTM SFKLTMFSLV LFSLSMVIFF ILDKTLIEQF IINMEMEKFS
     MTNNLINENI LSLNKMYNFP TNLITLLLIN YLFLTLLVTV KITKKFYGPL RPMN
 
 
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