ID   NU6M_BRACM              Reviewed;         205 AA.
AC   P60498; Q01825;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 6;
GN   Name=ND6; Synonyms=NAD6;
OS   Brassica campestris (Field mustard).
OG   Mitochondrion.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX   NCBI_TaxID=3711;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND RNA EDITING.
RX   PubMed=8431956; DOI=10.1007/bf00352014;
RA   Nugent J.M., Palmer J.D.;
RT   "Characterization of the Brassica campestris mitochondrial gene for subunit
RT   six of NADH dehydrogenase: nad6 is present in the mitochondrion of a wide
RT   range of flowering plants.";
RL   Curr. Genet. 23:148-153(1993).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBUNIT: Complex I is composed of about 45 different subunits.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- RNA EDITING: Modified_positions=Undetermined; Note=Comparison to ND6
CC       from other plants suggests this may be subjected to RNA editing.
CC       {ECO:0000305|PubMed:8431956};
CC   -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR   EMBL; X68256; CAA48326.1; -; Genomic_DNA.
DR   PIR; S28919; S28919.
DR   AlphaFoldDB; P60498; -.
DR   SMR; P60498; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.20.120.1200; -; 1.
DR   InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR   InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR   Pfam; PF00499; Oxidored_q3; 1.
PE   2: Evidence at transcript level;
KW   Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW   RNA editing; Translocase; Transmembrane; Transmembrane helix; Transport;
KW   Ubiquinone.
FT   CHAIN           1..205
FT                   /note="NADH-ubiquinone oxidoreductase chain 6"
FT                   /id="PRO_0000118251"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   205 AA;  23494 MW;  37997EA9D9AE660E CRC64;
     MILSVLSSPA LVSGLMVARA KNPVHSVLFP IPVFRDTSGL LLLLGLDFFA MIFPVVHIGA
     IAVSFLFVVM MFHIQIAEIH EEVLRYLPVS GIIGLIFWWE MFFILDNESI PLLPTQRNTT
     SLRYTVYAGK VRSWTNLETL GNLLYTYYSV WFLVPSLILL VAMIGAIVLT MHRTTKVKRQ
     DVFRRNAIDF RRTIMRRTTD PLTIY