ID   NU6M_BRAFL              Reviewed;         167 AA.
AC   P69232; O47432; O79423;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 6;
GN   Name=ND6; Synonyms=NAD6, NADH6;
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000312|Proteomes:UP000001554};
RX   PubMed=10331267; DOI=10.1093/oxfordjournals.molbev.a026122;
RA   Boore J.L., Daehler L.L., Brown W.M.;
RT   "Complete sequence, gene arrangement, and genetic code of mitochondrial DNA
RT   of the cephalochordate Branchiostoma floridae (Amphioxus).";
RL   Mol. Biol. Evol. 16:410-418(1999).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR   EMBL; AF098298; AAB88001.2; -; Genomic_DNA.
DR   RefSeq; NP_007766.1; NC_000834.1.
DR   AlphaFoldDB; P69232; -.
DR   GeneID; 808735; -.
DR   KEGG; bfo:808735; -.
DR   CTD; 4541; -.
DR   InParanoid; P69232; -.
DR   Proteomes; UP000001554; Mitochondrion.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR   Pfam; PF00499; Oxidored_q3; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; NAD; Reference proteome;
KW   Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..167
FT                   /note="NADH-ubiquinone oxidoreductase chain 6"
FT                   /id="PRO_0000118252"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   167 AA;  18731 MW;  A2CFAD8DC12E68DC CRC64;
     MQMMLMFLLL LAAIMVIRAT SPYYGALATA WLALLAALLL LDADIIFPAI ILMLIYLGGM
     LVVFIYSTAY AADLMPLPIN LTMSALMASF GVMLITMISS PSIETLCETK PWLVYDMQPS
     YMLFDIYQRG SSMFIVAVMI LTALLFSILE VVSHRQTTMK WFIHSTY