NU6M_CAEBR
ID NU6M_CAEBR Reviewed; 144 AA.
AC Q8HEC0; B1PE33; B1PE45; B1PEC9; B1PEF3; B1PEH7; B1PEN7;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-OCT-2009, sequence version 2.
DT 25-MAY-2022, entry version 55.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 6;
GN Name=nd6;
OS Caenorhabditis briggsae.
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS PHE-4; THR-46; PHE-86;
RP LEU-97; LYS-98 AND ALA-100.
RC STRAIN=BW287, ED3032, ED3033, ED3034, ED3035, ED3036, ED3037, ED3083,
RC ED3092, ED3101, EG4181, EG4207A, HK104, HK105, JU403, JU439, JU516, JU725,
RC JU726, JU793, PB800, PB826, and VT847;
RX PubMed=18302772; DOI=10.1186/1471-2148-8-62;
RA Howe D.K., Denver D.R.;
RT "Muller's Ratchet and compensatory mutation in Caenorhabditis briggsae
RT mitochondrial genome evolution.";
RL BMC Evol. Biol. 8:62-62(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-144, AND VARIANT THR-46.
RC STRAIN=PB800;
RX PubMed=12644560; DOI=10.1093/molbev/msg044;
RA Denver D.R., Morris K., Thomas W.K.;
RT "Phylogenetics in Caenorhabditis elegans: an analysis of divergence and
RT outcrossing.";
RL Mol. Biol. Evol. 20:393-400(2003).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR EMBL; EU407781; ACB06100.1; -; Genomic_DNA.
DR EMBL; EU407782; ACB06112.1; -; Genomic_DNA.
DR EMBL; EU407783; ACB06124.1; -; Genomic_DNA.
DR EMBL; EU407784; ACB06136.1; -; Genomic_DNA.
DR EMBL; EU407785; ACB06148.1; -; Genomic_DNA.
DR EMBL; EU407786; ACB06160.1; -; Genomic_DNA.
DR EMBL; EU407787; ACB06172.1; -; Genomic_DNA.
DR EMBL; EU407788; ACB06184.1; -; Genomic_DNA.
DR EMBL; EU407789; ACB06196.1; -; Genomic_DNA.
DR EMBL; EU407790; ACB06208.1; -; Genomic_DNA.
DR EMBL; EU407791; ACB06220.1; -; Genomic_DNA.
DR EMBL; EU407792; ACB06232.1; -; Genomic_DNA.
DR EMBL; EU407793; ACB06244.1; -; Genomic_DNA.
DR EMBL; EU407794; ACB06256.1; -; Genomic_DNA.
DR EMBL; EU407795; ACB06268.1; -; Genomic_DNA.
DR EMBL; EU407796; ACB06280.1; -; Genomic_DNA.
DR EMBL; EU407797; ACB06292.1; -; Genomic_DNA.
DR EMBL; EU407798; ACB06304.1; -; Genomic_DNA.
DR EMBL; EU407799; ACB06316.1; -; Genomic_DNA.
DR EMBL; EU407800; ACB06328.1; -; Genomic_DNA.
DR EMBL; EU407801; ACB06340.1; -; Genomic_DNA.
DR EMBL; EU407802; ACB06352.1; -; Genomic_DNA.
DR EMBL; EU407803; ACB06364.1; -; Genomic_DNA.
DR EMBL; AC186293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY171106; AAO13513.1; -; Genomic_DNA.
DR RefSeq; YP_133881.2; NC_009885.1.
DR AlphaFoldDB; Q8HEC0; -.
DR SMR; Q8HEC0; -.
DR GeneID; 5666629; -.
DR KEGG; cbr:ND6; -.
DR CTD; 4541; -.
DR InParanoid; Q8HEC0; -.
DR Proteomes; UP000008549; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Reference proteome;
KW Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..144
FT /note="NADH-ubiquinone oxidoreductase chain 6"
FT /id="PRO_0000118256"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 4
FT /note="L -> F (in strain: HK104 and HK105)"
FT /evidence="ECO:0000269|PubMed:18302772"
FT VARIANT 46
FT /note="I -> T (in strain: BW287, EG4181, EG4207A, HK104,
FT HK105, JU403, JU439, JU516, JU793, PB800 and PB826)"
FT /evidence="ECO:0000269|PubMed:12644560,
FT ECO:0000269|PubMed:18302772"
FT VARIANT 86
FT /note="L -> F (in strain: HK104 and HK105)"
FT /evidence="ECO:0000269|PubMed:18302772"
FT VARIANT 97
FT /note="M -> L (in strain: ED3092 and ED3101)"
FT /evidence="ECO:0000269|PubMed:18302772"
FT VARIANT 98
FT /note="E -> K (in strain: JU725)"
FT /evidence="ECO:0000269|PubMed:18302772"
FT VARIANT 100
FT /note="T -> A (in strain: ED3092 and ED3101)"
FT /evidence="ECO:0000269|PubMed:18302772"
SQ SEQUENCE 144 AA; 16980 MW; DEE833CB4AB35E99 CRC64;
MIKLFFVLAI FSSIISYMNI DPMKSSFFLI FSLLFSMPII SMSMHIWFSY FICLLFLSGI
FVILVYFSSL SKINVVKSYM SLFLLLISII YFSPVSMEYT NYLGLSGFYY SIYWFIFSFI
LICLLFFMNF SSYFLNFSGA LRKV
