ID   NU6M_CANLU              Reviewed;         175 AA.
AC   Q1HK79; Q1HKE4;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE            EC=7.1.1.2 {ECO:0000250|UniProtKB:P03923};
DE   AltName: Full=NADH dehydrogenase subunit 6;
GN   Name=MT-ND6; Synonyms=MTND6, NADH6, ND6;
OS   Canis lupus (Gray wolf).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT PHE-31.
RX   PubMed=16809672; DOI=10.1101/gr.5117706;
RA   Bjornerfeldt S., Webster M.T., Vila C.;
RT   "Relaxation of selective constraint on dog mitochondrial DNA following
RT   domestication.";
RL   Genome Res. 16:990-994(2006).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. Essential for the catalytic activity and assembly of complex
CC       I. {ECO:0000250|UniProtKB:P03923}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000250|UniProtKB:P03923};
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:P03924}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03924}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR   EMBL; DQ480503; ABE48166.1; -; Genomic_DNA.
DR   EMBL; DQ480504; ABE48179.1; -; Genomic_DNA.
DR   EMBL; DQ480505; ABE48192.1; -; Genomic_DNA.
DR   EMBL; DQ480506; ABE48205.1; -; Genomic_DNA.
DR   EMBL; DQ480507; ABE48218.1; -; Genomic_DNA.
DR   EMBL; DQ480508; ABE48231.1; -; Genomic_DNA.
DR   RefSeq; YP_626739.1; NC_008092.1.
DR   AlphaFoldDB; Q1HK79; -.
DR   SMR; Q1HK79; -.
DR   GeneID; 4097762; -.
DR   CTD; 4541; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   Gene3D; 1.20.120.1200; -; 1.
DR   InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR   InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR   Pfam; PF00499; Oxidored_q3; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..175
FT                   /note="NADH-ubiquinone oxidoreductase chain 6"
FT                   /id="PRO_0000269898"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VARIANT         31
FT                   /note="L -> F"
FT                   /evidence="ECO:0000269|PubMed:16809672"
SQ   SEQUENCE   175 AA;  18899 MW;  BEE89E92195E9C9E CRC64;
     MMTYIVFILS IVFVMSFVGF ATKPSPIYGG LVLIISGGIG CAIVLNFGGS FLGLMVFLIY
     LGGMLVVFGY TTAMATEQYP EVWVSNKAVL AAFITGLLSE LLTACYILKD DEVEVVLKFN
     GMGDWVIYDT GDSGFFSEEA MGIAALYSYG TWLVVVTGWS LLIGVLVIME VTRGN