NU6M_CANPA
ID NU6M_CANPA Reviewed; 155 AA.
AC P48923;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 6;
GN Name=ND6; Synonyms=NAD6;
OS Candida parapsilosis (Yeast).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=5480;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SR23 / CBS 7157;
RX PubMed=7521869; DOI=10.1128/jb.176.18.5622-5630.1994;
RA Nosek J., Fukuhara H.;
RT "NADH dehydrogenase subunit genes in the mitochondrial DNA of yeasts.";
RL J. Bacteriol. 176:5622-5630(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SR23 / CBS 7157;
RX PubMed=15449175; DOI=10.1007/s00438-004-1046-0;
RA Nosek J., Novotna M., Hlavatovicova Z., Ussery D.W., Fajkus J., Tomaska L.;
RT "Complete DNA sequence of the linear mitochondrial genome of the pathogenic
RT yeast Candida parapsilosis.";
RL Mol. Genet. Genomics 272:173-180(2004).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR EMBL; X74411; CAE54605.1; -; Genomic_DNA.
DR RefSeq; NP_943643.1; NC_005253.2.
DR AlphaFoldDB; P48923; -.
DR SMR; P48923; -.
DR GeneID; 2935010; -.
DR CGD; CAL0000144967; CapafMp11.
DR VEuPathDB; FungiDB:CapafMp11; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.120.1200; -; 1.
DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR Pfam; PF00499; Oxidored_q3; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..155
FT /note="NADH-ubiquinone oxidoreductase chain 6"
FT /id="PRO_0000118260"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 155 AA; 16966 MW; D527D1DF4FEC4C58 CRC64;
MFLISGISSI LAIGLLSPVQ SIVCLIVLFV SAAISLYSNG FVLMGILYVL IYVGAIAILF
LFILSLLNIE YNYKGTIHPL IFTILIICLI PLDLSYETYG IVENVNIAYP FNSLLDWDLE
LTTVGSLLYT EYAIPMILIG LILILSVIGA IAITK
