NU6M_CARAU
ID NU6M_CARAU Reviewed; 173 AA.
AC O78689;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 6;
GN Name=MT-ND6; Synonyms=MTND6, NADH6, ND6;
OS Carassius auratus (Goldfish).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Carassius.
OX NCBI_TaxID=7957;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AZ3 / Langsdorfi; TISSUE=Oocyte;
RA Murakami M., Yamashita Y., Fujitani H.;
RT "The complete sequence of mitochondrial genome from a gynogenetic triploid
RT 'ginbuna' (Carassius auratus langsdorfi).";
RL Zool. Sci. 15:335-337(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Cuvieri;
RA Murakami M.;
RT "Carassius auratus cuvieri mitochondrial DNA, complete sequence.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR EMBL; AB006953; BAA31249.1; -; Genomic_DNA.
DR EMBL; AB045144; BAB40359.1; -; Genomic_DNA.
DR RefSeq; NP_008599.1; NC_002079.1.
DR AlphaFoldDB; O78689; -.
DR Ensembl; ENSCART00000000034; ENSCARP00000000013; ENSCARG00000000034.
DR GeneID; 808424; -.
DR CTD; 4541; -.
DR Proteomes; UP000515129; Mitochondrion MT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.120.1200; -; 1.
DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR Pfam; PF00499; Oxidored_q3; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Reference proteome;
KW Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..173
FT /note="NADH-ubiquinone oxidoreductase chain 6"
FT /id="PRO_0000118261"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 173 AA; 18095 MW; 3F4E4B65AB50C30C CRC64;
MTYFMFLLLM ALVVGLVAVA SNPTPYFAAL GLVVAAGVGC GVLVGHGGSF LSLVLFLIYL
GGMLVVFAYS AALAAEPYPE AWGSRSVLGY VLVYLLGVGL VAGFFWGGWY EGSWVVVDGL
KEFSVLRGDV SGVAVMYSSG GGMLVICAWV LLLTLLVVLE LTRGLSRGAL RAV
