NU6M_CHICK
ID NU6M_CHICK Reviewed; 173 AA.
AC P18941;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03923};
DE AltName: Full=NADH dehydrogenase subunit 6;
GN Name=MT-ND6; Synonyms=MTND6, NADH6, ND6;
OS Gallus gallus (Chicken).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Red jungle fowl {ECO:0000312|Proteomes:UP000000539};
RX PubMed=2329578; DOI=10.1016/0022-2836(90)90225-b;
RA Desjardins P., Morais R.;
RT "Sequence and gene organization of the chicken mitochondrial genome. A
RT novel gene order in higher vertebrates.";
RL J. Mol. Biol. 212:599-634(1990).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03923}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03923};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03924}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03924}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR EMBL; X52392; CAA36637.1; -; Genomic_DNA.
DR PIR; S10199; S10199.
DR RefSeq; NP_006927.1; NC_001323.1.
DR AlphaFoldDB; P18941; -.
DR SMR; P18941; -.
DR STRING; 9031.ENSGALP00000034624; -.
DR PaxDb; P18941; -.
DR Ensembl; ENSGALT00000068151; ENSGALP00000047587; ENSGALG00000037838.
DR VEuPathDB; HostDB:geneid_63549497; -.
DR eggNOG; ENOG502S2Q2; Eukaryota.
DR GeneTree; ENSGT00390000003988; -.
DR HOGENOM; CLU_129718_0_0_1; -.
DR InParanoid; P18941; -.
DR OMA; YLGGMMV; -.
DR OrthoDB; 1438416at2759; -.
DR PhylomeDB; P18941; -.
DR TreeFam; TF343324; -.
DR Reactome; R-GGA-611105; Respiratory electron transport.
DR Reactome; R-GGA-6799198; Complex I biogenesis.
DR PRO; PR:P18941; -.
DR Proteomes; UP000000539; Mitochondrion.
DR Bgee; ENSGALG00000037838; Expressed in kidney and 13 other tissues.
DR ExpressionAtlas; P18941; baseline and differential.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR Gene3D; 1.20.120.1200; -; 1.
DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR Pfam; PF00499; Oxidored_q3; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..173
FT /note="NADH-ubiquinone oxidoreductase chain 6"
FT /id="PRO_0000118266"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 173 AA; 18226 MW; 653B972273CF0064 CRC64;
MTYFVIFLGI CFMLGVLAVA SNPSPYYGVV GLVVASVMGC GWLVSLGVSF VSLALFLVYL
GGMLVVFVYS VSLAADPYPE AWGDWRVVGY GLGFVLVVWM GVVLGGLVDF WKVGVVTVDG
GGVSFARLDF SGVAVFYSCG VGLFLVAGWG LLLALFVVLE LVRGLSRGAI RAV
