ID   NU6M_CHLRE              Reviewed;         162 AA.
AC   P10329;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 2.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 6;
GN   Name=ND6; Synonyms=NAD6;
OS   Chlamydomonas reinhardtii (Chlamydomonas smithii).
OG   Mitochondrion.
OC   Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC   CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX   NCBI_TaxID=3055;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cw15;
RX   PubMed=2734113; DOI=10.1093/nar/17.10.3993;
RA   Boer P.H., Gray M.W.;
RT   "Nucleotide sequence of a region encoding subunit 6 of NADH dehydrogenase
RT   (ND6) and tRNA(Trp) in Chlamydomonas reinhardtii mitochondrial DNA.";
RL   Nucleic Acids Res. 17:3993-3993(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cw15;
RA   Gray M.W.;
RL   Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-162.
RC   STRAIN=cw15;
RX   PubMed=3205746; DOI=10.1093/nar/16.23.11373;
RA   Ma D.-P., Yang Y.-W., Hasnain S.;
RT   "Nucleotide sequence of Chlamydomonas reinhardtii mitochondrial genes
RT   coding for subunit 6 of NADH dehydrogenase and tRNATrp.";
RL   Nucleic Acids Res. 16:11373-11373(1988).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR   EMBL; X54860; CAA38644.1; -; Genomic_DNA.
DR   EMBL; U03843; AAB93445.1; -; Genomic_DNA.
DR   EMBL; X12939; CAA31402.1; -; Genomic_DNA.
DR   PIR; S04367; S04367.
DR   RefSeq; NP_042569.1; NC_001638.1.
DR   AlphaFoldDB; P10329; -.
DR   SMR; P10329; -.
DR   STRING; 3055.AAB93445; -.
DR   TCDB; 3.D.1.6.4; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR   GeneID; 801500; -.
DR   KEGG; cre:ChrepMp06; -.
DR   HOGENOM; CLU_1637824_0_0_1; -.
DR   OrthoDB; 1501334at2759; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.20.120.1200; -; 1.
DR   InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR   InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR   Pfam; PF00499; Oxidored_q3; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW   Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..162
FT                   /note="NADH-ubiquinone oxidoreductase chain 6"
FT                   /id="PRO_0000118267"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        151..152
FT                   /note="RF -> CA (in Ref. 3; CAA31402)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   162 AA;  17748 MW;  28AC33C3C90361C6 CRC64;
     MFFENSAILL CALLSIAVGY TKSPFMSLMY SVMLFINSSF VLMMLGFEFL ALVNLLVYVG
     ALAVLFLFVI MLLEIPATEL RAYSRGWSTL GIFVFIINGV FQITPSMGPR GIITGLPGAE
     SITNLGHALY LYFADLLILN SLVLTVALFG RFAIAPVRTT GR