ID   NU6M_COTJA              Reviewed;         173 AA.
AC   P24981; Q8SEW2;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   26-SEP-2003, sequence version 3.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 6;
GN   Name=MT-ND6; Synonyms=MTND6, NADH6, ND6;
OS   Coturnix japonica (Japanese quail) (Coturnix coturnix japonica).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Perdicinae; Coturnix.
OX   NCBI_TaxID=93934;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Blood;
RX   PubMed=11736810; DOI=10.1046/j.1365-2052.2001.00795.x;
RA   Nishibori M., Hayashi T., Tsudzuki M., Yamamoto Y., Yasue H.;
RT   "Complete sequence of the Japanese quail (Coturnix japonica) mitochondrial
RT   genome and its genetic relationship with related species.";
RL   Anim. Genet. 32:380-385(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-77.
RC   TISSUE=Liver;
RX   PubMed=1706782; DOI=10.1007/bf02515387;
RA   Desjardins P., Morais R.;
RT   "Nucleotide sequence and evolution of coding and noncoding regions of a
RT   quail mitochondrial genome.";
RL   J. Mol. Evol. 32:153-161(1991).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR   EMBL; AP003195; BAB62927.1; -; Genomic_DNA.
DR   EMBL; X57245; CAA40521.1; -; Genomic_DNA.
DR   PIR; S25425; S25425.
DR   RefSeq; NP_572026.1; NC_003408.1.
DR   AlphaFoldDB; P24981; -.
DR   Ensembl; ENSCJPT00005000037; ENSCJPP00005000014; ENSCJPG00005000037.
DR   GeneID; 804663; -.
DR   KEGG; cjo:804663; -.
DR   CTD; 4541; -.
DR   GeneTree; ENSGT00390000003988; -.
DR   OrthoDB; 1438416at2759; -.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:Ensembl.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:Ensembl.
DR   Gene3D; 1.20.120.1200; -; 1.
DR   InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR   InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR   Pfam; PF00499; Oxidored_q3; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW   Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..173
FT                   /note="NADH-ubiquinone oxidoreductase chain 6"
FT                   /id="PRO_0000118269"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   173 AA;  18364 MW;  88CF0912D46DE03D CRC64;
     MTYFVIFLGV CFMLGTLAVA SNPSPYYGVV GLVLASVVGC GWLVNLGVSF VSLVLFMIYL
     GGMLVVFVYS VSLAADPYPE AWGSWRVMGY GLGFVLVVCM GMGLGGFVDF WKIGVTTVDS
     GGMSFVRLDF GGVAAFYSYG VGLFLVAGWG LLLVLFVVLE LVRGLSRGAI RAV