NU6M_CYPCA
ID NU6M_CYPCA Reviewed; 172 AA.
AC P24982;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-1992, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 6;
GN Name=MT-ND6; Synonyms=MTND6, NADH6, ND6;
OS Cyprinus carpio (Common carp).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Cyprinus.
OX NCBI_TaxID=7962;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8169959; DOI=10.1007/bf00166161;
RA Chang Y.S., Huang F.L., Lo T.B.;
RT "The complete nucleotide sequence and gene organization of carp (Cyprinus
RT carpio) mitochondrial genome.";
RL J. Mol. Evol. 38:138-155(1994).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR EMBL; X61010; CAA43338.1; -; Genomic_DNA.
DR PIR; S36007; S36007.
DR RefSeq; NP_007093.1; NC_001606.1.
DR AlphaFoldDB; P24982; -.
DR SMR; P24982; -.
DR Ensembl; ENSCCRT00000000034; ENSCCRP00000000013; ENSCCRG00000000034.
DR GeneID; 807762; -.
DR KEGG; ccar:807762; -.
DR CTD; 4541; -.
DR GeneTree; ENSGT00390000003988; -.
DR OrthoDB; 1438416at2759; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR Pfam; PF00499; Oxidored_q3; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..172
FT /note="NADH-ubiquinone oxidoreductase chain 6"
FT /id="PRO_0000118273"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 172 AA; 17972 MW; B3EBBADA8B88E5E8 CRC64;
MTYFMFLLLM ALVVGLVAVA SNPTPYFAAL GLVVAAGVGC GVLVGHGGSF LSLVLFLIYL
GGMLVVFAYA ALAAEPFPEA WGSRSVLGYV LVYLLGVGLV AGIFWGGWYE GSWVVVDGLK
EFSVLRGDIS GVAVMYSSGG GMLVICAWVL LLTLLVVLEL TRGLSRGALR AV