ID   NU6M_DICDI              Reviewed;         226 AA.
AC   Q37314;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 6;
GN   Name=nad6; ORFNames=DDB_G0294028;
OS   Dictyostelium discoideum (Slime mold).
OG   Mitochondrion.
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AX3;
RX   PubMed=7736610; DOI=10.1007/bf00326157;
RA   Angata K., Kuroe K., Yanagisawa K., Tanaka Y.;
RT   "Codon usage, genetic code and phylogeny of Dictyostelium discoideum
RT   mitochondrial DNA as deduced from a 7.3-kb region.";
RL   Curr. Genet. 27:249-256(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX3;
RX   PubMed=10821186; DOI=10.1007/pl00008685;
RA   Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K., Matsuo K.,
RA   Morio T., Urushihara H., Yanagisawa K., Tanaka Y.;
RT   "The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene
RT   content and genome organization.";
RL   Mol. Gen. Genet. 263:514-519(2000).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR   EMBL; D16466; BAA03936.1; -; Genomic_DNA.
DR   EMBL; AB000109; BAA78064.1; -; Genomic_DNA.
DR   PIR; S68158; S68158.
DR   RefSeq; NP_050082.1; NC_000895.1.
DR   AlphaFoldDB; Q37314; -.
DR   SMR; Q37314; -.
DR   GeneID; 2193908; -.
DR   KEGG; ddi:DidioMp15; -.
DR   dictyBase; DDB_G0294028; nad6.
DR   InParanoid; Q37314; -.
DR   OMA; YTYYFVW; -.
DR   PRO; PR:Q37314; -.
DR   Proteomes; UP000002195; Mitochondrion.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IBA:GO_Central.
DR   Gene3D; 1.20.120.1200; -; 1.
DR   InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR   InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR   Pfam; PF00499; Oxidored_q3; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; NAD; Reference proteome;
KW   Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..226
FT                   /note="NADH-ubiquinone oxidoreductase chain 6"
FT                   /id="PRO_0000118275"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   226 AA;  25888 MW;  9D186877C958680F CRC64;
     MSTLGLLIML LGIIIMCTLV ILRSVNPIYS ILNLIVIYGC YASILLTVEM EFLACIYILV
     NVGAIAVLFL FIVMMININI VEIQETMKKY NIYMIVGIIG VVGLLGILIT NYQIRIKEEV
     IADFSMFLIN SEVVQLQATP SYLDFYSLFV ETTDIRTMGS NVIYGSYSIW FIMACIILLI
     GMVGVIYITE DLIIEKRTLN ERRRQDINSQ VLREYKITIR NYRESK