NU6M_DROYA
ID NU6M_DROYA Reviewed; 174 AA.
AC P07709;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 2.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 6;
GN Name=mt:ND6; Synonyms=ND6;
OS Drosophila yakuba (Fruit fly).
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6328435; DOI=10.1093/nar/12.9.3747;
RA Clary D.O., Wahleithner J.A., Wolstenholme D.R.;
RT "Sequence and arrangement of the genes for cytochrome b, URF1, URF4L, URF4,
RT URF5, URF6 and five tRNAs in Drosophila mitochondrial DNA.";
RL Nucleic Acids Res. 12:3747-3762(1984).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2317.6 Ivory Coast;
RX PubMed=3001325; DOI=10.1007/bf02099755;
RA Clary D.O., Wolstenholme D.R.;
RT "The mitochondrial DNA molecular of Drosophila yakuba: nucleotide sequence,
RT gene organization, and genetic code.";
RL J. Mol. Evol. 22:252-271(1985).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR EMBL; X03240; CAA26995.1; -; Genomic_DNA.
DR PIR; B30020; B30020.
DR RefSeq; NP_006912.1; NC_001322.1.
DR AlphaFoldDB; P07709; -.
DR GeneID; 807629; -.
DR KEGG; dya:ND6; -.
DR CTD; 4541; -.
DR FlyBase; FBgn0013187; Dyak\mt:ND6.
DR Proteomes; UP000002282; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR Pfam; PF00499; Oxidored_q3; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..174
FT /note="NADH-ubiquinone oxidoreductase chain 6"
FT /id="PRO_0000118279"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 174 AA; 20200 MW; 469DA42041574C57 CRC64;
MIQLMLYSLI ITTSIIFFNM IHPLALGLTL LIQTIFVCLL SGLMTKSFWY SYILFLIFLG
GMLVLFIYVT SLASNEMFNL SIKLTLFSMF ILFFMFILSM ILDKTSITLF LMNNEMQSII
EMNSYFTENS LSLNKLYNFP TNFVTILLMN YLLITLIVVV KITKLFKGPI RMMS
