ID   NU6M_FELCA              Reviewed;         175 AA.
AC   P48926;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE            EC=7.1.1.2 {ECO:0000250|UniProtKB:P03923};
DE   AltName: Full=NADH dehydrogenase subunit 6;
GN   Name=MT-ND6; Synonyms=MTND6, NADH6, ND6;
OS   Felis catus (Cat) (Felis silvestris catus).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000312|Proteomes:UP000011712}; TISSUE=Blood;
RX   PubMed=8660972; DOI=10.1006/geno.1996.0188;
RA   Lopez J.V., Cevario S., O'Brien S.J.;
RT   "Complete nucleotide sequences of the domestic cat (Felis catus)
RT   mitochondrial genome and a transposed mtDNA tandem repeat (Numt) in the
RT   nuclear genome.";
RL   Genomics 33:229-246(1996).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. Essential for the catalytic activity and assembly of complex
CC       I. {ECO:0000250|UniProtKB:P03923}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000250|UniProtKB:P03923};
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:P03924}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03924}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR   EMBL; U20753; AAC48580.1; -; Genomic_DNA.
DR   PIR; T11413; T11413.
DR   RefSeq; NP_008262.1; NC_001700.1.
DR   AlphaFoldDB; P48926; -.
DR   SMR; P48926; -.
DR   STRING; 9685.ENSFCAP00000025720; -.
DR   Ensembl; ENSFCAT00000032660; ENSFCAP00000025720; ENSFCAG00000032075.
DR   GeneID; 807930; -.
DR   KEGG; fca:807930; -.
DR   CTD; 4541; -.
DR   VGNC; VGNC:80938; MT-ND6.
DR   eggNOG; ENOG502S2Q2; Eukaryota.
DR   GeneTree; ENSGT00390000003988; -.
DR   HOGENOM; CLU_129718_0_0_1; -.
DR   InParanoid; P48926; -.
DR   OMA; YLGGMMV; -.
DR   OrthoDB; 1438416at2759; -.
DR   Proteomes; UP000011712; Mitochondrion.
DR   Bgee; ENSFCAG00000032075; Expressed in embryonic head and 9 other tissues.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   Gene3D; 1.20.120.1200; -; 1.
DR   InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR   InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR   Pfam; PF00499; Oxidored_q3; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..175
FT                   /note="NADH-ubiquinone oxidoreductase chain 6"
FT                   /id="PRO_0000118282"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   175 AA;  18784 MW;  B2290DE6D6D8B45F CRC64;
     MMTYIVFILS TVFVVSFVSF SSKPSPIYGG FGLIVAGGTG CGIVLNFGGS FLGLMVFLIY
     LGGMLVVFGY TTAMATEPYP EAWTSNKAVL AMFITGVLAE LLTACYILKE DEVEVVFKFN
     GAGDWVIYDT GDSGFFSEEA MGIAALYSYG TWLVVVTGWS LLIGVLVIME VTRGN