ID   NU6M_FORLA              Reviewed;         173 AA.
AC   P34196;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 6;
GN   Name=MT-ND6; Synonyms=MTND6, NADH6, ND6;
OS   Formosania lacustris (Oriental stream loach) (Crossostoma lacustre).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Gastromyzontidae; Formosania.
OX   NCBI_TaxID=7980;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1408800; DOI=10.1093/nar/20.18.4853;
RA   Tzeng C.-S., Hui C.-F., Shen S.-C., Huang P.C.;
RT   "The complete nucleotide sequence of the Crossostoma lacustre mitochondrial
RT   genome: conservation and variations among vertebrates.";
RL   Nucleic Acids Res. 20:4853-4858(1992).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR   EMBL; M91245; AAB96822.1; -; Genomic_DNA.
DR   PIR; S35472; S35472.
DR   RefSeq; NP_008314.1; NC_001727.1.
DR   AlphaFoldDB; P34196; -.
DR   SMR; P34196; -.
DR   GeneID; 807989; -.
DR   CTD; 4541; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR   Pfam; PF00499; Oxidored_q3; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW   Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..173
FT                   /note="NADH-ubiquinone oxidoreductase chain 6"
FT                   /id="PRO_0000118270"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   173 AA;  18297 MW;  A1F46176D848B412 CRC64;
     MTYLVSLLLM ALIVGLIAVA SNPAPYFAAL GLVVAAGVGC GVLVSHGGSF LSLVLFLIYL
     GGMLVVFAYS AALAAEPFPE AWGDRSVVGY VMIYLLGVGL MVGVFWEGWY EGSWVVIDGL
     KEFSVLRGDT SGVAEMYSYG GGMLVICAWV LLLTLFVVLE LTRGLSRGTI RAV