ID   NU6M_HORSE              Reviewed;         175 AA.
AC   P48657;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE            EC=7.1.1.2 {ECO:0000250|UniProtKB:P03923};
DE   AltName: Full=NADH dehydrogenase subunit 6;
GN   Name=MT-ND6; Synonyms=MTND6, NADH6, ND6;
OS   Equus caballus (Horse).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000312|Proteomes:UP000002281};
RX   PubMed=7958969; DOI=10.1016/0378-1119(94)90713-7;
RA   Xu X., Arnason U.;
RT   "The complete mitochondrial DNA sequence of the horse, Equus caballus:
RT   extensive heteroplasmy of the control region.";
RL   Gene 148:357-362(1994).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. Essential for the catalytic activity and assembly of complex
CC       I. {ECO:0000250|UniProtKB:P03923}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000250|UniProtKB:P03923};
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:P03924}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03924}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X79547; CAA56090.1; -; Genomic_DNA.
DR   PIR; T11868; T11868.
DR   RefSeq; NP_007171.1; NC_001640.1.
DR   AlphaFoldDB; P48657; -.
DR   SMR; P48657; -.
DR   STRING; 9796.ENSECAP00000023108; -.
DR   PaxDb; P48657; -.
DR   Ensembl; ENSECAT00000029841; ENSECAP00000023108; ENSECAG00000027677.
DR   GeneID; 807848; -.
DR   KEGG; ecb:807848; -.
DR   CTD; 4541; -.
DR   VGNC; VGNC:99803; MT-ND6.
DR   GeneTree; ENSGT00390000003988; -.
DR   HOGENOM; CLU_129718_0_0_1; -.
DR   InParanoid; P48657; -.
DR   OMA; YLGGMMV; -.
DR   OrthoDB; 1438416at2759; -.
DR   Proteomes; UP000002281; Mitochondrion.
DR   Bgee; ENSECAG00000027677; Expressed in retina and 23 other tissues.
DR   ExpressionAtlas; P48657; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   Gene3D; 1.20.120.1200; -; 1.
DR   InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR   InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR   Pfam; PF00499; Oxidored_q3; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..175
FT                   /note="NADH-ubiquinone oxidoreductase chain 6"
FT                   /id="PRO_0000118290"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   175 AA;  18670 MW;  F1D9229225E6B432 CRC64;
     MMTYIVFILS VIFVVSFVGF SSKPSPIYGG LVLIVSGGVG CGIIMNFGGS FLGLMVFLIY
     LGGMLVVFGY TTAMATEQYP EVWVSNTTVM GVFLLGLLME VMLVLYVLKS EEVGVVFKFS
     GVGAWAIYDT GDSGAFSEEI MGAAALYSYG AWVVIVTGWS LLVGVLVILE VTRGD