位置:首页 > 蛋白库 > NU6M_HUMAN
NU6M_HUMAN
ID   NU6M_HUMAN              Reviewed;         174 AA.
AC   P03923; Q34774; Q8HG30;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   03-AUG-2022, entry version 197.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE            EC=7.1.1.2 {ECO:0000269|PubMed:14595656, ECO:0000269|PubMed:8644732};
DE   AltName: Full=NADH dehydrogenase subunit 6;
GN   Name=MT-ND6; Synonyms=MTND6, NADH6, ND6;
OS   Homo sapiens (Human).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7219534; DOI=10.1038/290457a0;
RA   Anderson S., Bankier A.T., Barrell B.G., de Bruijn M.H.L., Coulson A.R.,
RA   Drouin J., Eperon I.C., Nierlich D.P., Roe B.A., Sanger F., Schreier P.H.,
RA   Smith A.J.H., Staden R., Young I.G.;
RT   "Sequence and organization of the human mitochondrial genome.";
RL   Nature 290:457-465(1981).
RN   [2]
RP   SEQUENCE REVISION TO 102; 134 AND 159.
RA   Kogelnik A., Brown M.;
RL   Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Placenta;
RX   PubMed=7530363; DOI=10.1073/pnas.92.2.532;
RA   Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N.;
RT   "Recent African origin of modern humans revealed by complete sequences of
RT   hominoid mitochondrial DNAs.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LHON VAL-64.
RX   PubMed=9452107; DOI=10.1002/humu.1380110186;
RA   Sudoyo H., Sitepu M., Malik S., Poesponegoro H.D., Marzuki S.;
RT   "Leber's hereditary optic neuropathy in Indonesia: two families with the
RT   mtDNA 11778G>A and 14484T>C mutations.";
RL   Hum. Mutat. Suppl. 1:S271-S274(1998).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12949126; DOI=10.1093/molbev/msg230;
RA   Moilanen J.S., Finnila S., Majamaa K.;
RT   "Lineage-specific selection in human mtDNA: lack of polymorphisms in a
RT   segment of MTND5 gene in haplogroup J.";
RL   Mol. Biol. Evol. 20:2132-2142(2003).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11130070; DOI=10.1038/35047064;
RA   Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.;
RT   "Mitochondrial genome variation and the origin of modern humans.";
RL   Nature 408:708-713(2000).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12840039; DOI=10.1101/gr.686603;
RA   Ingman M., Gyllensten U.;
RT   "Mitochondrial genome variation and evolutionary history of Australian and
RT   New Guinean aborigines.";
RL   Genome Res. 13:1600-1606(2003).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=14760490; DOI=10.1007/s00414-004-0427-6;
RA   Coble M.D., Just R.S., O'Callaghan J.E., Letmanyi I.H., Peterson C.T.,
RA   Irwin J.A., Parsons T.J.;
RT   "Single nucleotide polymorphisms over the entire mtDNA genome that increase
RT   the power of forensic testing in Caucasians.";
RL   Int. J. Legal Med. 118:137-146(2004).
RN   [9]
RP   VARIANT VAL-58.
RX   PubMed=2043137; DOI=10.1016/0006-291x(91)92014-b;
RA   Ozawa T., Tanaka M., Sugiyama S., Ino H., Ohno K., Hattori K.,
RA   Ohbayashi T., Ito T., Deguchi H., Kawamura K., Nakane Y., Hashiba K.;
RT   "Patients with idiopathic cardiomyopathy belong to the same mitochondrial
RT   DNA gene family of Parkinson's disease and mitochondrial
RT   encephalomyopathy.";
RL   Biochem. Biophys. Res. Commun. 177:518-525(1991).
RN   [10]
RP   VARIANT CYS-165.
RX   PubMed=1757091; DOI=10.1007/bf00206061;
RA   Marzuki S., Noer A.S., Lertrit P., Thyagarajan D., Kapsa R.,
RA   Utthanaphol P., Byrne E.;
RT   "Normal variants of human mitochondrial DNA and translation products: the
RT   building of a reference data base.";
RL   Hum. Genet. 88:139-145(1991).
RN   [11]
RP   VARIANT LHON VAL-64.
RX   PubMed=1417830; DOI=10.1016/0006-291x(92)90479-5;
RA   Johns D.R., Neufeld M.J., Park R.D.;
RT   "An ND-6 mitochondrial DNA mutation associated with Leber hereditary optic
RT   neuropathy.";
RL   Biochem. Biophys. Res. Commun. 187:1551-1557(1992).
RN   [12]
RP   VARIANT LDYT VAL-72.
RX   PubMed=8016139; DOI=10.1073/pnas.91.13.6206;
RA   Jun A.S., Brown M.D., Wallace D.C.;
RT   "A mitochondrial DNA mutation at nucleotide pair 14459 of the NADH
RT   dehydrogenase subunit 6 gene associated with maternally inherited Leber
RT   hereditary optic neuropathy and dystonia.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:6206-6210(1994).
RN   [13]
RP   VARIANT LDYT MET-26, CHARACTERIZATION OF VARIANT LDYT MET-26, FUNCTION, AND
RP   CATALYTIC ACTIVITY.
RX   PubMed=8644732;
RA   de Vries D.D., Went L.N., Bruyn G.W., Scholte H.R., Hofstra R.M.W.,
RA   Bolhuis P.A., van Oost B.A.;
RT   "Genetic and biochemical impairment of mitochondrial complex I activity in
RT   a family with Leber hereditary optic neuropathy and hereditary spastic
RT   dystonia.";
RL   Am. J. Hum. Genet. 58:703-711(1996).
RN   [14]
RP   VARIANT LHON CYS-59.
RX   PubMed=8854108;
RA   Leo-Kottler B., Christ-Adler M., Baumann B., Zrenner E., Wissinger B.;
RT   "Leber's hereditary optic neuropathy: clinical and molecular genetic
RT   results obtained in a family with a new point mutation at nucleotide
RT   position 14498 in the ND 6 gene.";
RL   Ger. J. Ophthalmol. 5:233-240(1996).
RN   [15]
RP   VARIANT LHON SER-36.
RX   PubMed=10447650; DOI=10.1007/s004170050307;
RA   Besch D., Leo-Kottler B., Zrenner E., Wissinger B.;
RT   "Leber's hereditary optic neuropathy: clinical and molecular genetic
RT   findings in a patient with a new mutation in the ND6 gene.";
RL   Graefes Arch. Clin. Exp. Ophthalmol. 237:745-752(1999).
RN   [16]
RP   VARIANT LHON SER-60, AND VARIANTS ALA-31 AND VAL-33.
RX   PubMed=11133798; DOI=10.1093/brain/124.1.209;
RA   Chinnery P.F., Brown D.T., Andrews R.M., Singh-Kler R., Riordan-Eva P.,
RA   Lindley J., Applegarth D.A., Turnbull D.M., Howell N.;
RT   "The mitochondrial ND6 gene is a hot spot for mutations that cause Leber's
RT   hereditary optic neuropathy.";
RL   Brain 124:209-218(2001).
RN   [17]
RP   VARIANT MELAS VAL-74.
RX   PubMed=11781695; DOI=10.1038/sj.ejhg.5200712;
RA   Ravn K., Wibrand F., Hansen F.J., Horn N., Rosenberg T., Schwartz M.;
RT   "An mtDNA mutation, 14453G-->A, in the NADH dehydrogenase subunit 6
RT   associated with severe MELAS syndrome.";
RL   Eur. J. Hum. Genet. 9:805-809(2001).
RN   [18]
RP   VARIANT LS VAL-63, CHARACTERIZATION OF LS VAL-63, FUNCTION, AND CATALYTIC
RP   ACTIVITY.
RX   PubMed=14595656; DOI=10.1002/ana.10734;
RA   Ugalde C., Triepels R.H., Coenen M.J., van den Heuvel L.P., Smeets R.,
RA   Uusimaa J., Briones P., Campistol J., Majamaa K., Smeitink J.A.,
RA   Nijtmans L.G.;
RT   "Impaired complex I assembly in a Leigh syndrome patient with a novel
RT   missense mutation in the ND6 gene.";
RL   Ann. Neurol. 54:665-669(2003).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor (PubMed:8644732, PubMed:14595656). Essential for the catalytic
CC       activity and assembly of complex I (PubMed:8644732, PubMed:14595656).
CC       {ECO:0000269|PubMed:14595656, ECO:0000269|PubMed:8644732}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000269|PubMed:14595656, ECO:0000269|PubMed:8644732};
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:P03924}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03924}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- DISEASE: Leber hereditary optic neuropathy (LHON) [MIM:535000]: A
CC       maternally inherited form of Leber hereditary optic neuropathy, a
CC       mitochondrial disease resulting in bilateral painless loss of central
CC       vision due to selective degeneration of the retinal ganglion cells and
CC       their axons. The disorder shows incomplete penetrance and male
CC       predominance. Cardiac conduction defects and neurological defects have
CC       also been described in some LHON patients. LHON results from primary
CC       mitochondrial DNA mutations affecting the respiratory chain complexes.
CC       {ECO:0000269|PubMed:10447650, ECO:0000269|PubMed:11133798,
CC       ECO:0000269|PubMed:1417830, ECO:0000269|PubMed:8854108,
CC       ECO:0000269|PubMed:9452107}. Note=The disease is caused by variants
CC       affecting the gene represented in this entry.
CC   -!- DISEASE: Leber hereditary optic neuropathy with dystonia (LDYT)
CC       [MIM:500001]: A form of Leber hereditary optic neuropathy, a
CC       mitochondrial disease resulting in bilateral painless loss of central
CC       vision due to selective degeneration of the retinal ganglion cells and
CC       their axons. The disorder shows incomplete penetrance and male
CC       predominance. LDYT is characterized by the association of optic atrophy
CC       and central vision loss with dystonia. {ECO:0000269|PubMed:8016139,
CC       ECO:0000269|PubMed:8644732}. Note=The disease is caused by variants
CC       affecting the gene represented in this entry.
CC   -!- DISEASE: Mitochondrial encephalomyopathy with lactic acidosis and
CC       stroke-like episodes syndrome (MELAS) [MIM:540000]: Genetically
CC       heterogeneous disorder, characterized by episodic vomiting, seizures,
CC       and recurrent cerebral insults resembling strokes and causing
CC       hemiparesis, hemianopsia, or cortical blindness.
CC       {ECO:0000269|PubMed:11781695}. Note=The disease is caused by variants
CC       affecting the gene represented in this entry.
CC   -!- DISEASE: Leigh syndrome (LS) [MIM:256000]: An early-onset progressive
CC       neurodegenerative disorder characterized by the presence of focal,
CC       bilateral lesions in one or more areas of the central nervous system
CC       including the brainstem, thalamus, basal ganglia, cerebellum and spinal
CC       cord. Clinical features depend on which areas of the central nervous
CC       system are involved and include subacute onset of psychomotor
CC       retardation, hypotonia, ataxia, weakness, vision loss, eye movement
CC       abnormalities, seizures, and dysphagia. {ECO:0000269|PubMed:14595656}.
CC       Note=The disease is caused by variants affecting the gene represented
CC       in this entry.
CC   -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; J01415; AAB58954.1; -; Genomic_DNA.
DR   EMBL; V00662; CAA24037.1; -; Genomic_DNA.
DR   EMBL; D38112; BAA07298.1; -; Genomic_DNA.
DR   EMBL; AY063322; AAL47640.1; -; Genomic_DNA.
DR   EMBL; AY339402; AAP89047.1; -; Genomic_DNA.
DR   EMBL; AY339403; AAP89060.1; -; Genomic_DNA.
DR   EMBL; AY339404; AAP89073.1; -; Genomic_DNA.
DR   EMBL; AY339405; AAP89086.1; -; Genomic_DNA.
DR   EMBL; AY339406; AAP89099.1; -; Genomic_DNA.
DR   EMBL; AY339407; AAP89112.1; -; Genomic_DNA.
DR   EMBL; AY339408; AAP89125.1; -; Genomic_DNA.
DR   EMBL; AY339409; AAP89138.1; -; Genomic_DNA.
DR   EMBL; AY339410; AAP89151.1; -; Genomic_DNA.
DR   EMBL; AY339411; AAP89164.1; -; Genomic_DNA.
DR   EMBL; AY339413; AAP89190.1; -; Genomic_DNA.
DR   EMBL; AY339414; AAP89203.1; -; Genomic_DNA.
DR   EMBL; AY339415; AAP89216.1; -; Genomic_DNA.
DR   EMBL; AY339416; AAP89229.1; -; Genomic_DNA.
DR   EMBL; AY339417; AAP89242.1; -; Genomic_DNA.
DR   EMBL; AY339418; AAP89255.1; -; Genomic_DNA.
DR   EMBL; AY339419; AAP89268.1; -; Genomic_DNA.
DR   EMBL; AY339420; AAP89281.1; -; Genomic_DNA.
DR   EMBL; AY339421; AAP89294.1; -; Genomic_DNA.
DR   EMBL; AY339422; AAP89307.1; -; Genomic_DNA.
DR   EMBL; AY339423; AAP89320.1; -; Genomic_DNA.
DR   EMBL; AY339424; AAP89333.1; -; Genomic_DNA.
DR   EMBL; AY339425; AAP89346.1; -; Genomic_DNA.
DR   EMBL; AY339426; AAP89359.1; -; Genomic_DNA.
DR   EMBL; AY339427; AAP89372.1; -; Genomic_DNA.
DR   EMBL; AY339428; AAP89385.1; -; Genomic_DNA.
DR   EMBL; AY339429; AAP89398.1; -; Genomic_DNA.
DR   EMBL; AY339430; AAP89411.1; -; Genomic_DNA.
DR   EMBL; AY339431; AAP89424.1; -; Genomic_DNA.
DR   EMBL; AY339432; AAP89437.1; -; Genomic_DNA.
DR   EMBL; AY339433; AAP89450.1; -; Genomic_DNA.
DR   EMBL; AY339434; AAP89463.1; -; Genomic_DNA.
DR   EMBL; AY339435; AAP89476.1; -; Genomic_DNA.
DR   EMBL; AY339436; AAP89489.1; -; Genomic_DNA.
DR   EMBL; AY339437; AAP89502.1; -; Genomic_DNA.
DR   EMBL; AY339438; AAP89515.1; -; Genomic_DNA.
DR   EMBL; AY339439; AAP89528.1; -; Genomic_DNA.
DR   EMBL; AY339440; AAP89541.1; -; Genomic_DNA.
DR   EMBL; AY339441; AAP89554.1; -; Genomic_DNA.
DR   EMBL; AY339442; AAP89567.1; -; Genomic_DNA.
DR   EMBL; AY339443; AAP89580.1; -; Genomic_DNA.
DR   EMBL; AY339444; AAP89593.1; -; Genomic_DNA.
DR   EMBL; AY339445; AAP89606.1; -; Genomic_DNA.
DR   EMBL; AY339446; AAP89619.1; -; Genomic_DNA.
DR   EMBL; AY339447; AAP89632.1; -; Genomic_DNA.
DR   EMBL; AY339448; AAP89645.1; -; Genomic_DNA.
DR   EMBL; AY339449; AAP89658.1; -; Genomic_DNA.
DR   EMBL; AY339450; AAP89671.1; -; Genomic_DNA.
DR   EMBL; AY339455; AAP89736.1; -; Genomic_DNA.
DR   EMBL; AY339456; AAP89749.1; -; Genomic_DNA.
DR   EMBL; AY339457; AAP89762.1; -; Genomic_DNA.
DR   EMBL; AY339458; AAP89775.1; -; Genomic_DNA.
DR   EMBL; AY339459; AAP89788.1; -; Genomic_DNA.
DR   EMBL; AY339460; AAP89801.1; -; Genomic_DNA.
DR   EMBL; AY339461; AAP89814.1; -; Genomic_DNA.
DR   EMBL; AY339462; AAP89827.1; -; Genomic_DNA.
DR   EMBL; AY339463; AAP89840.1; -; Genomic_DNA.
DR   EMBL; AY339464; AAP89853.1; -; Genomic_DNA.
DR   EMBL; AY339465; AAP89866.1; -; Genomic_DNA.
DR   EMBL; AY339466; AAP89879.1; -; Genomic_DNA.
DR   EMBL; AY339467; AAP89892.1; -; Genomic_DNA.
DR   EMBL; AY339468; AAP89905.1; -; Genomic_DNA.
DR   EMBL; AY339469; AAP89918.1; -; Genomic_DNA.
DR   EMBL; AY339470; AAP89931.1; -; Genomic_DNA.
DR   EMBL; AY339471; AAP89944.1; -; Genomic_DNA.
DR   EMBL; AY339472; AAP89957.1; -; Genomic_DNA.
DR   EMBL; AY339473; AAP89970.1; -; Genomic_DNA.
DR   EMBL; AY339474; AAP89983.1; -; Genomic_DNA.
DR   EMBL; AY339475; AAP89996.1; -; Genomic_DNA.
DR   EMBL; AY339476; AAP90009.1; -; Genomic_DNA.
DR   EMBL; AY339477; AAP90022.1; -; Genomic_DNA.
DR   EMBL; AY339478; AAP90035.1; -; Genomic_DNA.
DR   EMBL; AY339479; AAP90048.1; -; Genomic_DNA.
DR   EMBL; AY339480; AAP90061.1; -; Genomic_DNA.
DR   EMBL; AY339481; AAP90074.1; -; Genomic_DNA.
DR   EMBL; AY339482; AAP90087.1; -; Genomic_DNA.
DR   EMBL; AY339483; AAP90100.1; -; Genomic_DNA.
DR   EMBL; AY339484; AAP90113.1; -; Genomic_DNA.
DR   EMBL; AY339485; AAP90126.1; -; Genomic_DNA.
DR   EMBL; AY339486; AAP90139.1; -; Genomic_DNA.
DR   EMBL; AY339487; AAP90152.1; -; Genomic_DNA.
DR   EMBL; AY339488; AAP90165.1; -; Genomic_DNA.
DR   EMBL; AY339489; AAP90178.1; -; Genomic_DNA.
DR   EMBL; AY339490; AAP90191.1; -; Genomic_DNA.
DR   EMBL; AY339491; AAP90204.1; -; Genomic_DNA.
DR   EMBL; AY339492; AAP90217.1; -; Genomic_DNA.
DR   EMBL; AY339493; AAP90230.1; -; Genomic_DNA.
DR   EMBL; AY339494; AAP90243.1; -; Genomic_DNA.
DR   EMBL; AY339495; AAP90256.1; -; Genomic_DNA.
DR   EMBL; AY339496; AAP90269.1; -; Genomic_DNA.
DR   EMBL; AY339497; AAP90282.1; -; Genomic_DNA.
DR   EMBL; AY339498; AAP90295.1; -; Genomic_DNA.
DR   EMBL; AY339499; AAP90308.1; -; Genomic_DNA.
DR   EMBL; AY339500; AAP90321.1; -; Genomic_DNA.
DR   EMBL; AY339501; AAP90334.1; -; Genomic_DNA.
DR   EMBL; AY339502; AAP90347.1; -; Genomic_DNA.
DR   EMBL; AY339503; AAP90360.1; -; Genomic_DNA.
DR   EMBL; AY339504; AAP90373.1; -; Genomic_DNA.
DR   EMBL; AY339505; AAP90386.1; -; Genomic_DNA.
DR   EMBL; AY339506; AAP90399.1; -; Genomic_DNA.
DR   EMBL; AY339507; AAP90412.1; -; Genomic_DNA.
DR   EMBL; AY339508; AAP90425.1; -; Genomic_DNA.
DR   EMBL; AY339509; AAP90438.1; -; Genomic_DNA.
DR   EMBL; AY339510; AAP90451.1; -; Genomic_DNA.
DR   EMBL; AY339511; AAP90464.1; -; Genomic_DNA.
DR   EMBL; AY339512; AAP90477.1; -; Genomic_DNA.
DR   EMBL; AY339513; AAP90490.1; -; Genomic_DNA.
DR   EMBL; AY339514; AAP90503.1; -; Genomic_DNA.
DR   EMBL; AY339515; AAP90516.1; -; Genomic_DNA.
DR   EMBL; AY339516; AAP90529.1; -; Genomic_DNA.
DR   EMBL; AY339517; AAP90542.1; -; Genomic_DNA.
DR   EMBL; AY339518; AAP90555.1; -; Genomic_DNA.
DR   EMBL; AY339519; AAP90568.1; -; Genomic_DNA.
DR   EMBL; AY339520; AAP90581.1; -; Genomic_DNA.
DR   EMBL; AY339521; AAP90594.1; -; Genomic_DNA.
DR   EMBL; AY339522; AAP90607.1; -; Genomic_DNA.
DR   EMBL; AY339523; AAP90620.1; -; Genomic_DNA.
DR   EMBL; AY339524; AAP90633.1; -; Genomic_DNA.
DR   EMBL; AY339525; AAP90646.1; -; Genomic_DNA.
DR   EMBL; AY339526; AAP90659.1; -; Genomic_DNA.
DR   EMBL; AY339528; AAP90685.1; -; Genomic_DNA.
DR   EMBL; AY339529; AAP90698.1; -; Genomic_DNA.
DR   EMBL; AY339530; AAP90711.1; -; Genomic_DNA.
DR   EMBL; AY339531; AAP90724.1; -; Genomic_DNA.
DR   EMBL; AY339532; AAP90737.1; -; Genomic_DNA.
DR   EMBL; AY339533; AAP90750.1; -; Genomic_DNA.
DR   EMBL; AY339534; AAP90763.1; -; Genomic_DNA.
DR   EMBL; AY339535; AAP90776.1; -; Genomic_DNA.
DR   EMBL; AY339536; AAP90789.1; -; Genomic_DNA.
DR   EMBL; AY339537; AAP90802.1; -; Genomic_DNA.
DR   EMBL; AY339538; AAP90815.1; -; Genomic_DNA.
DR   EMBL; AY339539; AAP90828.1; -; Genomic_DNA.
DR   EMBL; AY339540; AAP90841.1; -; Genomic_DNA.
DR   EMBL; AY339541; AAP90854.1; -; Genomic_DNA.
DR   EMBL; AY339542; AAP90867.1; -; Genomic_DNA.
DR   EMBL; AY339543; AAP90880.1; -; Genomic_DNA.
DR   EMBL; AY339544; AAP90893.1; -; Genomic_DNA.
DR   EMBL; AY339545; AAP90906.1; -; Genomic_DNA.
DR   EMBL; AY339546; AAP90919.1; -; Genomic_DNA.
DR   EMBL; AY339547; AAP90932.1; -; Genomic_DNA.
DR   EMBL; AY339548; AAP90945.1; -; Genomic_DNA.
DR   EMBL; AY339549; AAP90958.1; -; Genomic_DNA.
DR   EMBL; AY339550; AAP90971.1; -; Genomic_DNA.
DR   EMBL; AY339551; AAP90984.1; -; Genomic_DNA.
DR   EMBL; AY339552; AAP90997.1; -; Genomic_DNA.
DR   EMBL; AY339553; AAP91010.1; -; Genomic_DNA.
DR   EMBL; AY339554; AAP91023.1; -; Genomic_DNA.
DR   EMBL; AY339555; AAP91036.1; -; Genomic_DNA.
DR   EMBL; AY339556; AAP91049.1; -; Genomic_DNA.
DR   EMBL; AY339557; AAP91062.1; -; Genomic_DNA.
DR   EMBL; AY339558; AAP91075.1; -; Genomic_DNA.
DR   EMBL; AY339559; AAP91088.1; -; Genomic_DNA.
DR   EMBL; AY339560; AAP91101.1; -; Genomic_DNA.
DR   EMBL; AY339561; AAP91114.1; -; Genomic_DNA.
DR   EMBL; AY339562; AAP91127.1; -; Genomic_DNA.
DR   EMBL; AY339563; AAP91140.1; -; Genomic_DNA.
DR   EMBL; AY339564; AAP91153.1; -; Genomic_DNA.
DR   EMBL; AY339565; AAP91166.1; -; Genomic_DNA.
DR   EMBL; AY339566; AAP91179.1; -; Genomic_DNA.
DR   EMBL; AY339567; AAP91192.1; -; Genomic_DNA.
DR   EMBL; AY339568; AAP91205.1; -; Genomic_DNA.
DR   EMBL; AY339569; AAP91218.1; -; Genomic_DNA.
DR   EMBL; AY339570; AAP91231.1; -; Genomic_DNA.
DR   EMBL; AY339571; AAP91244.1; -; Genomic_DNA.
DR   EMBL; AY339572; AAP91257.1; -; Genomic_DNA.
DR   EMBL; AY339573; AAP91270.1; -; Genomic_DNA.
DR   EMBL; AY339574; AAP91283.1; -; Genomic_DNA.
DR   EMBL; AY339575; AAP91296.1; -; Genomic_DNA.
DR   EMBL; AY339576; AAP91309.1; -; Genomic_DNA.
DR   EMBL; AY339577; AAP91322.1; -; Genomic_DNA.
DR   EMBL; AY339578; AAP91335.1; -; Genomic_DNA.
DR   EMBL; AY339579; AAP91348.1; -; Genomic_DNA.
DR   EMBL; AY339580; AAP91361.1; -; Genomic_DNA.
DR   EMBL; AY339581; AAP91374.1; -; Genomic_DNA.
DR   EMBL; AY339582; AAP91387.1; -; Genomic_DNA.
DR   EMBL; AY339583; AAP91400.1; -; Genomic_DNA.
DR   EMBL; AY339584; AAP91413.1; -; Genomic_DNA.
DR   EMBL; AY339585; AAP91426.1; -; Genomic_DNA.
DR   EMBL; AY339586; AAP91439.1; -; Genomic_DNA.
DR   EMBL; AY339587; AAP91452.1; -; Genomic_DNA.
DR   EMBL; AY339588; AAP91465.1; -; Genomic_DNA.
DR   EMBL; AY339589; AAP91478.1; -; Genomic_DNA.
DR   EMBL; AY339590; AAP91491.1; -; Genomic_DNA.
DR   EMBL; AY339591; AAP91504.1; -; Genomic_DNA.
DR   EMBL; AY339592; AAP91517.1; -; Genomic_DNA.
DR   EMBL; AY339593; AAP91530.1; -; Genomic_DNA.
DR   EMBL; AF346964; AAK17231.1; -; Genomic_DNA.
DR   EMBL; AF346965; AAK17244.1; -; Genomic_DNA.
DR   EMBL; AF346966; AAK17257.1; -; Genomic_DNA.
DR   EMBL; AF346967; AAK17270.1; -; Genomic_DNA.
DR   EMBL; AF346971; AAK17322.1; -; Genomic_DNA.
DR   EMBL; AF346972; AAK17335.1; -; Genomic_DNA.
DR   EMBL; AF346973; AAK17348.1; -; Genomic_DNA.
DR   EMBL; AF346974; AAK17361.1; -; Genomic_DNA.
DR   EMBL; AF346975; AAK17374.1; -; Genomic_DNA.
DR   EMBL; AF346976; AAK17387.1; -; Genomic_DNA.
DR   EMBL; AF346977; AAK17400.1; -; Genomic_DNA.
DR   EMBL; AF346978; AAK17413.1; -; Genomic_DNA.
DR   EMBL; AF346981; AAK17452.1; -; Genomic_DNA.
DR   EMBL; AF346982; AAK17465.1; -; Genomic_DNA.
DR   EMBL; AF346983; AAK17478.1; -; Genomic_DNA.
DR   EMBL; AF346984; AAK17491.1; -; Genomic_DNA.
DR   EMBL; AF346985; AAK17504.1; -; Genomic_DNA.
DR   EMBL; AF346988; AAK17543.1; -; Genomic_DNA.
DR   EMBL; AF346989; AAK17556.1; -; Genomic_DNA.
DR   EMBL; AF346990; AAK17569.1; -; Genomic_DNA.
DR   EMBL; AF346993; AAK17608.1; -; Genomic_DNA.
DR   EMBL; AF346994; AAK17621.1; -; Genomic_DNA.
DR   EMBL; AF346995; AAK17634.1; -; Genomic_DNA.
DR   EMBL; AF346998; AAK17673.1; -; Genomic_DNA.
DR   EMBL; AF346999; AAK17686.1; -; Genomic_DNA.
DR   EMBL; AF347000; AAK17699.1; -; Genomic_DNA.
DR   EMBL; AF347001; AAK17712.1; -; Genomic_DNA.
DR   EMBL; AF347002; AAK17725.1; -; Genomic_DNA.
DR   EMBL; AF347003; AAK17738.1; -; Genomic_DNA.
DR   EMBL; AF347004; AAK17751.1; -; Genomic_DNA.
DR   EMBL; AF347005; AAK17764.1; -; Genomic_DNA.
DR   EMBL; AF347006; AAK17777.1; -; Genomic_DNA.
DR   EMBL; AF347007; AAK17790.1; -; Genomic_DNA.
DR   EMBL; AF347008; AAK17803.1; -; Genomic_DNA.
DR   EMBL; AF347009; AAK17816.1; -; Genomic_DNA.
DR   EMBL; AF347010; AAK17829.1; -; Genomic_DNA.
DR   EMBL; AF347014; AAK17881.1; -; Genomic_DNA.
DR   EMBL; AF347015; AAK17894.1; -; Genomic_DNA.
DR   EMBL; AY289052; AAP47904.1; -; Genomic_DNA.
DR   EMBL; AY289053; AAP47917.1; -; Genomic_DNA.
DR   EMBL; AY289056; AAP47956.1; -; Genomic_DNA.
DR   EMBL; AY289057; AAP47969.1; -; Genomic_DNA.
DR   EMBL; AY289058; AAP47982.1; -; Genomic_DNA.
DR   EMBL; AY289059; AAP47995.1; -; Genomic_DNA.
DR   EMBL; AY289060; AAP48008.1; -; Genomic_DNA.
DR   EMBL; AY289062; AAP48034.1; -; Genomic_DNA.
DR   EMBL; AY289063; AAP48047.1; -; Genomic_DNA.
DR   EMBL; AY289064; AAP48060.1; -; Genomic_DNA.
DR   EMBL; AY289065; AAP48073.1; -; Genomic_DNA.
DR   EMBL; AY289066; AAP48086.1; -; Genomic_DNA.
DR   EMBL; AY289067; AAP48099.1; -; Genomic_DNA.
DR   EMBL; AY289068; AAP48112.1; -; Genomic_DNA.
DR   EMBL; AY289069; AAP48125.1; -; Genomic_DNA.
DR   EMBL; AY289070; AAP48138.1; -; Genomic_DNA.
DR   EMBL; AY289071; AAP48151.1; -; Genomic_DNA.
DR   EMBL; AY289072; AAP48164.1; -; Genomic_DNA.
DR   EMBL; AY289073; AAP48177.1; -; Genomic_DNA.
DR   EMBL; AY289074; AAP48190.1; -; Genomic_DNA.
DR   EMBL; AY289075; AAP48203.1; -; Genomic_DNA.
DR   EMBL; AY289076; AAP48216.1; -; Genomic_DNA.
DR   EMBL; AY289077; AAP48229.1; -; Genomic_DNA.
DR   EMBL; AY289078; AAP48242.1; -; Genomic_DNA.
DR   EMBL; AY289079; AAP48255.1; -; Genomic_DNA.
DR   EMBL; AY289080; AAP48268.1; -; Genomic_DNA.
DR   EMBL; AY289081; AAP48281.1; -; Genomic_DNA.
DR   EMBL; AY289082; AAP48294.1; -; Genomic_DNA.
DR   EMBL; AY289083; AAP48307.1; -; Genomic_DNA.
DR   EMBL; AY289084; AAP48320.1; -; Genomic_DNA.
DR   EMBL; AY289085; AAP48333.1; -; Genomic_DNA.
DR   EMBL; AY289086; AAP48346.1; -; Genomic_DNA.
DR   EMBL; AY289088; AAP48372.1; -; Genomic_DNA.
DR   EMBL; AY289089; AAP48385.1; -; Genomic_DNA.
DR   EMBL; AY289090; AAP48398.1; -; Genomic_DNA.
DR   EMBL; AY289091; AAP48411.1; -; Genomic_DNA.
DR   EMBL; AY289092; AAP48423.1; -; Genomic_DNA.
DR   EMBL; AY289093; AAP48436.1; -; Genomic_DNA.
DR   EMBL; AY289094; AAP48449.1; -; Genomic_DNA.
DR   EMBL; AY289095; AAP48462.1; -; Genomic_DNA.
DR   EMBL; AY289096; AAP48475.1; -; Genomic_DNA.
DR   EMBL; AY289097; AAP48488.1; -; Genomic_DNA.
DR   EMBL; AY289098; AAP48501.1; -; Genomic_DNA.
DR   EMBL; AY289099; AAP48514.1; -; Genomic_DNA.
DR   EMBL; AY289100; AAP48527.1; -; Genomic_DNA.
DR   EMBL; AY289101; AAP48540.1; -; Genomic_DNA.
DR   EMBL; AY289102; AAP48553.1; -; Genomic_DNA.
DR   EMBL; AY495090; AAR92507.1; -; Genomic_DNA.
DR   EMBL; AY495091; AAR92520.1; -; Genomic_DNA.
DR   EMBL; AY495092; AAR92533.1; -; Genomic_DNA.
DR   EMBL; AY495093; AAR92546.1; -; Genomic_DNA.
DR   EMBL; AY495094; AAR92559.1; -; Genomic_DNA.
DR   EMBL; AY495096; AAR92585.1; -; Genomic_DNA.
DR   EMBL; AY495097; AAR92598.1; -; Genomic_DNA.
DR   EMBL; AY495098; AAR92611.1; -; Genomic_DNA.
DR   EMBL; AY495099; AAR92624.1; -; Genomic_DNA.
DR   EMBL; AY495100; AAR92637.1; -; Genomic_DNA.
DR   EMBL; AY495101; AAR92650.1; -; Genomic_DNA.
DR   EMBL; AY495102; AAR92663.1; -; Genomic_DNA.
DR   EMBL; AY495103; AAR92676.1; -; Genomic_DNA.
DR   EMBL; AY495104; AAR92689.1; -; Genomic_DNA.
DR   EMBL; AY495105; AAR92702.1; -; Genomic_DNA.
DR   EMBL; AY495106; AAR92715.1; -; Genomic_DNA.
DR   EMBL; AY495107; AAR92728.1; -; Genomic_DNA.
DR   EMBL; AY495109; AAR92754.1; -; Genomic_DNA.
DR   EMBL; AY495110; AAR92767.1; -; Genomic_DNA.
DR   EMBL; AY495112; AAR92793.1; -; Genomic_DNA.
DR   EMBL; AY495113; AAR92806.1; -; Genomic_DNA.
DR   EMBL; AY495114; AAR92819.1; -; Genomic_DNA.
DR   EMBL; AY495115; AAR92832.1; -; Genomic_DNA.
DR   EMBL; AY495116; AAR92845.1; -; Genomic_DNA.
DR   EMBL; AY495117; AAR92858.1; -; Genomic_DNA.
DR   EMBL; AY495118; AAR92871.1; -; Genomic_DNA.
DR   EMBL; AY495119; AAR92884.1; -; Genomic_DNA.
DR   EMBL; AY495120; AAR92897.1; -; Genomic_DNA.
DR   EMBL; AY495121; AAR92910.1; -; Genomic_DNA.
DR   EMBL; AY495122; AAR92923.1; -; Genomic_DNA.
DR   EMBL; AY495124; AAR92949.1; -; Genomic_DNA.
DR   EMBL; AY495125; AAR92962.1; -; Genomic_DNA.
DR   EMBL; AY495126; AAR92975.1; -; Genomic_DNA.
DR   EMBL; AY495128; AAR93001.1; -; Genomic_DNA.
DR   EMBL; AY495129; AAR93014.1; -; Genomic_DNA.
DR   EMBL; AY495130; AAR93027.1; -; Genomic_DNA.
DR   EMBL; AY495131; AAR93040.1; -; Genomic_DNA.
DR   EMBL; AY495132; AAR93053.1; -; Genomic_DNA.
DR   EMBL; AY495133; AAR93066.1; -; Genomic_DNA.
DR   EMBL; AY495134; AAR93079.1; -; Genomic_DNA.
DR   EMBL; AY495135; AAR93092.1; -; Genomic_DNA.
DR   EMBL; AY495136; AAR93105.1; -; Genomic_DNA.
DR   EMBL; AY495137; AAR93118.1; -; Genomic_DNA.
DR   EMBL; AY495138; AAR93131.1; -; Genomic_DNA.
DR   EMBL; AY495139; AAR93144.1; -; Genomic_DNA.
DR   EMBL; AY495140; AAR93157.1; -; Genomic_DNA.
DR   EMBL; AY495141; AAR93170.1; -; Genomic_DNA.
DR   EMBL; AY495142; AAR93183.1; -; Genomic_DNA.
DR   EMBL; AY495143; AAR93196.1; -; Genomic_DNA.
DR   EMBL; AY495144; AAR93209.1; -; Genomic_DNA.
DR   EMBL; AY495145; AAR93222.1; -; Genomic_DNA.
DR   EMBL; AY495146; AAR93235.1; -; Genomic_DNA.
DR   EMBL; AY495147; AAR93248.1; -; Genomic_DNA.
DR   EMBL; AY495148; AAR93261.1; -; Genomic_DNA.
DR   EMBL; AY495149; AAR93274.1; -; Genomic_DNA.
DR   EMBL; AY495150; AAR93287.1; -; Genomic_DNA.
DR   EMBL; AY495151; AAR93300.1; -; Genomic_DNA.
DR   EMBL; AY495152; AAR93313.1; -; Genomic_DNA.
DR   EMBL; AY495153; AAR93326.1; -; Genomic_DNA.
DR   EMBL; AY495154; AAR93339.1; -; Genomic_DNA.
DR   EMBL; AY495155; AAR93352.1; -; Genomic_DNA.
DR   EMBL; AY495156; AAR93365.1; -; Genomic_DNA.
DR   EMBL; AY495157; AAR93378.1; -; Genomic_DNA.
DR   EMBL; AY495158; AAR93391.1; -; Genomic_DNA.
DR   EMBL; AY495159; AAR93404.1; -; Genomic_DNA.
DR   EMBL; AY495160; AAR93417.1; -; Genomic_DNA.
DR   EMBL; AY495161; AAR93430.1; -; Genomic_DNA.
DR   EMBL; AY495162; AAR93443.1; -; Genomic_DNA.
DR   EMBL; AY495163; AAR93456.1; -; Genomic_DNA.
DR   EMBL; AY495164; AAR93469.1; -; Genomic_DNA.
DR   EMBL; AY495165; AAR93482.1; -; Genomic_DNA.
DR   EMBL; AY495166; AAR93495.1; -; Genomic_DNA.
DR   EMBL; AY495167; AAR93508.1; -; Genomic_DNA.
DR   EMBL; AY495168; AAR93521.1; -; Genomic_DNA.
DR   EMBL; AY495169; AAR93534.1; -; Genomic_DNA.
DR   EMBL; AY495170; AAR93547.1; -; Genomic_DNA.
DR   EMBL; AY495171; AAR93560.1; -; Genomic_DNA.
DR   EMBL; AY495172; AAR93573.1; -; Genomic_DNA.
DR   EMBL; AY495173; AAR93586.1; -; Genomic_DNA.
DR   EMBL; AY495174; AAR93599.1; -; Genomic_DNA.
DR   EMBL; AY495175; AAR93612.1; -; Genomic_DNA.
DR   EMBL; AY495176; AAR93625.1; -; Genomic_DNA.
DR   EMBL; AY495177; AAR93638.1; -; Genomic_DNA.
DR   EMBL; AY495180; AAR93677.1; -; Genomic_DNA.
DR   EMBL; AY495185; AAR93742.1; -; Genomic_DNA.
DR   EMBL; AY495187; AAR93768.1; -; Genomic_DNA.
DR   EMBL; AY495188; AAR93781.1; -; Genomic_DNA.
DR   EMBL; AY495189; AAR93794.1; -; Genomic_DNA.
DR   EMBL; AY495190; AAR93807.1; -; Genomic_DNA.
DR   EMBL; AY495191; AAR93820.1; -; Genomic_DNA.
DR   EMBL; AY495192; AAR93833.1; -; Genomic_DNA.
DR   EMBL; AY495193; AAR93846.1; -; Genomic_DNA.
DR   EMBL; AY495194; AAR93859.1; -; Genomic_DNA.
DR   EMBL; AY495195; AAR93872.1; -; Genomic_DNA.
DR   EMBL; AY495196; AAR93885.1; -; Genomic_DNA.
DR   EMBL; AY495197; AAR93898.1; -; Genomic_DNA.
DR   EMBL; AY495198; AAR93911.1; -; Genomic_DNA.
DR   EMBL; AY495199; AAR93924.1; -; Genomic_DNA.
DR   EMBL; AY495200; AAR93937.1; -; Genomic_DNA.
DR   EMBL; AY495201; AAR93950.1; -; Genomic_DNA.
DR   EMBL; AY495202; AAR93963.1; -; Genomic_DNA.
DR   EMBL; AY495203; AAR93976.1; -; Genomic_DNA.
DR   EMBL; AY495204; AAR93989.1; -; Genomic_DNA.
DR   EMBL; AY495205; AAR94002.1; -; Genomic_DNA.
DR   EMBL; AY495206; AAR94015.1; -; Genomic_DNA.
DR   EMBL; AY495207; AAR94028.1; -; Genomic_DNA.
DR   EMBL; AY495208; AAR94041.1; -; Genomic_DNA.
DR   EMBL; AY495210; AAR94067.1; -; Genomic_DNA.
DR   EMBL; AY495211; AAR94080.1; -; Genomic_DNA.
DR   EMBL; AY495212; AAR94093.1; -; Genomic_DNA.
DR   EMBL; AY495213; AAR94106.1; -; Genomic_DNA.
DR   EMBL; AY495214; AAR94119.1; -; Genomic_DNA.
DR   EMBL; AY495216; AAR94145.1; -; Genomic_DNA.
DR   EMBL; AY495217; AAR94158.1; -; Genomic_DNA.
DR   EMBL; AY495218; AAR94171.1; -; Genomic_DNA.
DR   EMBL; AY495219; AAR94184.1; -; Genomic_DNA.
DR   EMBL; AY495220; AAR94197.1; -; Genomic_DNA.
DR   EMBL; AY495221; AAR94210.1; -; Genomic_DNA.
DR   EMBL; AY495222; AAR94223.1; -; Genomic_DNA.
DR   EMBL; AY495223; AAR94236.1; -; Genomic_DNA.
DR   EMBL; AY495224; AAR94249.1; -; Genomic_DNA.
DR   EMBL; AY495225; AAR94262.1; -; Genomic_DNA.
DR   EMBL; AY495226; AAR94275.1; -; Genomic_DNA.
DR   EMBL; AY495227; AAR94288.1; -; Genomic_DNA.
DR   EMBL; AY495228; AAR94301.1; -; Genomic_DNA.
DR   EMBL; AY495229; AAR94314.1; -; Genomic_DNA.
DR   EMBL; AY495230; AAR94327.1; -; Genomic_DNA.
DR   EMBL; AY495231; AAR94340.1; -; Genomic_DNA.
DR   EMBL; AY495232; AAR94353.1; -; Genomic_DNA.
DR   EMBL; AY495233; AAR94366.1; -; Genomic_DNA.
DR   EMBL; AY495234; AAR94379.1; -; Genomic_DNA.
DR   EMBL; AY495235; AAR94392.1; -; Genomic_DNA.
DR   EMBL; AY495236; AAR94405.1; -; Genomic_DNA.
DR   EMBL; AY495237; AAR94418.1; -; Genomic_DNA.
DR   EMBL; AY495238; AAR94431.1; -; Genomic_DNA.
DR   EMBL; AY495239; AAR94444.1; -; Genomic_DNA.
DR   EMBL; AY495240; AAR94457.1; -; Genomic_DNA.
DR   EMBL; AY495241; AAR94470.1; -; Genomic_DNA.
DR   EMBL; AY495242; AAR94483.1; -; Genomic_DNA.
DR   EMBL; AY495243; AAR94496.1; -; Genomic_DNA.
DR   EMBL; AY495244; AAR94509.1; -; Genomic_DNA.
DR   EMBL; AY495245; AAR94522.1; -; Genomic_DNA.
DR   EMBL; AY495246; AAR94535.1; -; Genomic_DNA.
DR   EMBL; AY495247; AAR94548.1; -; Genomic_DNA.
DR   EMBL; AY495248; AAR94561.1; -; Genomic_DNA.
DR   EMBL; AY495249; AAR94574.1; -; Genomic_DNA.
DR   EMBL; AY495250; AAR94587.1; -; Genomic_DNA.
DR   EMBL; AY495251; AAR94600.1; -; Genomic_DNA.
DR   EMBL; AY495252; AAR94613.1; -; Genomic_DNA.
DR   EMBL; AY495253; AAR94626.1; -; Genomic_DNA.
DR   EMBL; AY495254; AAR94639.1; -; Genomic_DNA.
DR   EMBL; AY495255; AAR94652.1; -; Genomic_DNA.
DR   EMBL; AY495256; AAR94665.1; -; Genomic_DNA.
DR   EMBL; AY495257; AAR94678.1; -; Genomic_DNA.
DR   EMBL; AY495258; AAR94691.1; -; Genomic_DNA.
DR   EMBL; AY495259; AAR94704.1; -; Genomic_DNA.
DR   EMBL; AY495261; AAR94730.1; -; Genomic_DNA.
DR   EMBL; AY495262; AAR94743.1; -; Genomic_DNA.
DR   EMBL; AY495263; AAR94756.1; -; Genomic_DNA.
DR   EMBL; AY495264; AAR94769.1; -; Genomic_DNA.
DR   EMBL; AY495266; AAR94795.1; -; Genomic_DNA.
DR   EMBL; AY495267; AAR94808.1; -; Genomic_DNA.
DR   EMBL; AY495268; AAR94821.1; -; Genomic_DNA.
DR   EMBL; AY495269; AAR94834.1; -; Genomic_DNA.
DR   EMBL; AY495270; AAR94847.1; -; Genomic_DNA.
DR   EMBL; AY495271; AAR94860.1; -; Genomic_DNA.
DR   EMBL; AY495272; AAR94873.1; -; Genomic_DNA.
DR   EMBL; AY495273; AAR94886.1; -; Genomic_DNA.
DR   EMBL; AY495274; AAR94899.1; -; Genomic_DNA.
DR   EMBL; AY495275; AAR94912.1; -; Genomic_DNA.
DR   EMBL; AY495276; AAR94925.1; -; Genomic_DNA.
DR   EMBL; AY495277; AAR94938.1; -; Genomic_DNA.
DR   EMBL; AY495278; AAR94951.1; -; Genomic_DNA.
DR   EMBL; AY495279; AAR94964.1; -; Genomic_DNA.
DR   EMBL; AY495280; AAR94977.1; -; Genomic_DNA.
DR   EMBL; AY495281; AAR94990.1; -; Genomic_DNA.
DR   EMBL; AY495282; AAR95003.1; -; Genomic_DNA.
DR   EMBL; AY495283; AAR95016.1; -; Genomic_DNA.
DR   EMBL; AY495284; AAR95029.1; -; Genomic_DNA.
DR   EMBL; AY495285; AAR95042.1; -; Genomic_DNA.
DR   EMBL; AY495286; AAR95055.1; -; Genomic_DNA.
DR   EMBL; AY495287; AAR95068.1; -; Genomic_DNA.
DR   EMBL; AY495288; AAR95081.1; -; Genomic_DNA.
DR   EMBL; AY495289; AAR95094.1; -; Genomic_DNA.
DR   EMBL; AY495290; AAR95107.1; -; Genomic_DNA.
DR   EMBL; AY495291; AAR95120.1; -; Genomic_DNA.
DR   EMBL; AY495292; AAR95133.1; -; Genomic_DNA.
DR   EMBL; AY495293; AAR95146.1; -; Genomic_DNA.
DR   EMBL; AY495294; AAR95159.1; -; Genomic_DNA.
DR   EMBL; AY495295; AAR95172.1; -; Genomic_DNA.
DR   EMBL; AY495296; AAR95185.1; -; Genomic_DNA.
DR   EMBL; AY495297; AAR95198.1; -; Genomic_DNA.
DR   EMBL; AY495298; AAR95211.1; -; Genomic_DNA.
DR   EMBL; AY495299; AAR95224.1; -; Genomic_DNA.
DR   EMBL; AY495300; AAR95237.1; -; Genomic_DNA.
DR   EMBL; AY495301; AAR95250.1; -; Genomic_DNA.
DR   EMBL; AY495302; AAR95263.1; -; Genomic_DNA.
DR   EMBL; AY495303; AAR95276.1; -; Genomic_DNA.
DR   EMBL; AY495304; AAR95289.1; -; Genomic_DNA.
DR   EMBL; AY495305; AAR95302.1; -; Genomic_DNA.
DR   EMBL; AY495306; AAR95315.1; -; Genomic_DNA.
DR   EMBL; AY495307; AAR95328.1; -; Genomic_DNA.
DR   EMBL; AY495308; AAR95341.1; -; Genomic_DNA.
DR   EMBL; AY495310; AAR95367.1; -; Genomic_DNA.
DR   EMBL; AY495311; AAR95380.1; -; Genomic_DNA.
DR   EMBL; AY495312; AAR95393.1; -; Genomic_DNA.
DR   EMBL; AY495313; AAR95406.1; -; Genomic_DNA.
DR   EMBL; AY495314; AAR95419.1; -; Genomic_DNA.
DR   EMBL; AY495315; AAR95432.1; -; Genomic_DNA.
DR   EMBL; AY495316; AAR95445.1; -; Genomic_DNA.
DR   EMBL; AY495317; AAR95458.1; -; Genomic_DNA.
DR   EMBL; AY495318; AAR95471.1; -; Genomic_DNA.
DR   EMBL; AY495319; AAR95484.1; -; Genomic_DNA.
DR   EMBL; AY495320; AAR95497.1; -; Genomic_DNA.
DR   EMBL; AY495321; AAR95510.1; -; Genomic_DNA.
DR   EMBL; AY495322; AAR95523.1; -; Genomic_DNA.
DR   EMBL; AY495323; AAR95536.1; -; Genomic_DNA.
DR   EMBL; AY495324; AAR95549.1; -; Genomic_DNA.
DR   EMBL; AY495325; AAR95562.1; -; Genomic_DNA.
DR   EMBL; AY495326; AAR95575.1; -; Genomic_DNA.
DR   EMBL; AY495327; AAR95588.1; -; Genomic_DNA.
DR   EMBL; AY495328; AAR95601.1; -; Genomic_DNA.
DR   EMBL; AY495329; AAR95614.1; -; Genomic_DNA.
DR   EMBL; AY495330; AAR95627.1; -; Genomic_DNA.
DR   PIR; A00455; DEHUN6.
DR   RefSeq; YP_003024037.1; NC_012920.1.
DR   PDB; 5XTC; EM; 3.70 A; m=1-174.
DR   PDB; 5XTD; EM; 3.70 A; m=1-174.
DR   PDBsum; 5XTC; -.
DR   PDBsum; 5XTD; -.
DR   AlphaFoldDB; P03923; -.
DR   SMR; P03923; -.
DR   BioGRID; 110637; 7.
DR   ComplexPortal; CPX-577; Mitochondrial respiratory chain complex I.
DR   CORUM; P03923; -.
DR   IntAct; P03923; 6.
DR   MINT; P03923; -.
DR   STRING; 9606.ENSP00000354665; -.
DR   BindingDB; P03923; -.
DR   ChEMBL; CHEMBL2363065; -.
DR   DrugBank; DB00157; NADH.
DR   DrugCentral; P03923; -.
DR   BioMuta; MT-ND6; -.
DR   DMDM; 6648060; -.
DR   EPD; P03923; -.
DR   jPOST; P03923; -.
DR   MassIVE; P03923; -.
DR   PaxDb; P03923; -.
DR   PeptideAtlas; P03923; -.
DR   PRIDE; P03923; -.
DR   ProteomicsDB; 51617; -.
DR   TopDownProteomics; P03923; -.
DR   Antibodypedia; 35364; 99 antibodies from 20 providers.
DR   DNASU; 4541; -.
DR   Ensembl; ENST00000361681.2; ENSP00000354665.2; ENSG00000198695.2.
DR   GeneID; 4541; -.
DR   KEGG; hsa:4541; -.
DR   CTD; 4541; -.
DR   DisGeNET; 4541; -.
DR   GeneCards; MT-ND6; -.
DR   GeneReviews; MT-ND6; -.
DR   HGNC; HGNC:7462; MT-ND6.
DR   HPA; ENSG00000198695; Tissue enhanced (heart muscle, skeletal muscle).
DR   MalaCards; MT-ND6; -.
DR   MIM; 256000; phenotype.
DR   MIM; 500001; phenotype.
DR   MIM; 516006; gene.
DR   MIM; 535000; phenotype.
DR   MIM; 540000; phenotype.
DR   neXtProt; NX_P03923; -.
DR   OpenTargets; ENSG00000198695; -.
DR   Orphanet; 104; Leber hereditary optic neuropathy.
DR   Orphanet; 99718; Leber plus disease.
DR   Orphanet; 550; MELAS.
DR   Orphanet; 255210; Mitochondrial DNA-associated Leigh syndrome.
DR   PharmGKB; PA31266; -.
DR   VEuPathDB; HostDB:ENSG00000198695; -.
DR   eggNOG; ENOG502S2Q2; Eukaryota.
DR   GeneTree; ENSGT00390000003988; -.
DR   HOGENOM; CLU_129718_0_0_1; -.
DR   InParanoid; P03923; -.
DR   OMA; YLGGMMV; -.
DR   OrthoDB; 1438416at2759; -.
DR   PhylomeDB; P03923; -.
DR   TreeFam; TF343324; -.
DR   BioCyc; MetaCyc:HS00036-MON; -.
DR   PathwayCommons; P03923; -.
DR   Reactome; R-HSA-611105; Respiratory electron transport.
DR   Reactome; R-HSA-6799198; Complex I biogenesis.
DR   SignaLink; P03923; -.
DR   SIGNOR; P03923; -.
DR   BioGRID-ORCS; 4541; 0 hits in 2 CRISPR screens.
DR   ChiTaRS; MT-ND6; human.
DR   GeneWiki; MT-ND6; -.
DR   GenomeRNAi; 4541; -.
DR   Pharos; P03923; Tclin.
DR   PRO; PR:P03923; -.
DR   Proteomes; UP000005640; Mitochondrion.
DR   RNAct; P03923; protein.
DR   Bgee; ENSG00000198695; Expressed in mucosa of stomach and 96 other tissues.
DR   ExpressionAtlas; P03923; baseline and differential.
DR   Genevisible; P03923; HS.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IDA:ComplexPortal.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IPI:ComplexPortal.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IMP:UniProtKB.
DR   GO; GO:0009060; P:aerobic respiration; IC:ComplexPortal.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IMP:UniProtKB.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
DR   GO; GO:0042776; P:proton motive force-driven mitochondrial ATP synthesis; IC:ComplexPortal.
DR   GO; GO:0042220; P:response to cocaine; IEA:Ensembl.
DR   GO; GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
DR   GO; GO:0035094; P:response to nicotine; IEA:Ensembl.
DR   InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR   Pfam; PF00499; Oxidored_q3; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Disease variant; Dystonia; Electron transport;
KW   Leber hereditary optic neuropathy; Leigh syndrome; MELAS syndrome;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; NAD;
KW   Primary mitochondrial disease; Reference proteome; Respiratory chain;
KW   Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..174
FT                   /note="NADH-ubiquinone oxidoreductase chain 6"
FT                   /id="PRO_0000118291"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VARIANT         26
FT                   /note="I -> M (in LDYT; possible rare primary mutation;
FT                   decrease in enzyme activity; dbSNP:rs387906424)"
FT                   /evidence="ECO:0000269|PubMed:8644732"
FT                   /id="VAR_008394"
FT   VARIANT         31
FT                   /note="V -> A (in dbSNP:rs41354845)"
FT                   /evidence="ECO:0000269|PubMed:11133798"
FT                   /id="VAR_014393"
FT   VARIANT         33
FT                   /note="I -> V (in dbSNP:rs386829219)"
FT                   /evidence="ECO:0000269|PubMed:11133798"
FT                   /id="VAR_014394"
FT   VARIANT         36
FT                   /note="G -> S (in LHON; possible rare primary mutation;
FT                   dbSNP:rs397515506)"
FT                   /evidence="ECO:0000269|PubMed:10447650"
FT                   /id="VAR_008395"
FT   VARIANT         58
FT                   /note="I -> V (in dbSNP:rs201327354)"
FT                   /evidence="ECO:0000269|PubMed:2043137"
FT                   /id="VAR_014395"
FT   VARIANT         59
FT                   /note="Y -> C (in LHON; possible rare primary mutation;
FT                   dbSNP:rs869025186)"
FT                   /evidence="ECO:0000269|PubMed:8854108"
FT                   /id="VAR_008396"
FT   VARIANT         60
FT                   /note="L -> S (in LHON; possible rare primary mutation;
FT                   dbSNP:rs199476106)"
FT                   /evidence="ECO:0000269|PubMed:11133798"
FT                   /id="VAR_014396"
FT   VARIANT         63
FT                   /note="M -> V (in LS; decrease in enzyme activity and
FT                   impaired assembly of complex I; dbSNP:rs199476109)"
FT                   /evidence="ECO:0000269|PubMed:14595656"
FT                   /id="VAR_064568"
FT   VARIANT         64
FT                   /note="M -> I (in LHON; possible rare primary mutation;
FT                   dbSNP:rs199476108)"
FT                   /id="VAR_008512"
FT   VARIANT         64
FT                   /note="M -> V (in LHON; primary mutation; low severity; up
FT                   to 50% of vision recovery; dbSNP:rs199476104)"
FT                   /evidence="ECO:0000269|PubMed:1417830,
FT                   ECO:0000269|PubMed:9452107"
FT                   /id="VAR_004763"
FT   VARIANT         72
FT                   /note="A -> V (in LDYT; most severe mutation with no vision
FT                   recovery; dbSNP:rs199476105)"
FT                   /evidence="ECO:0000269|PubMed:8016139"
FT                   /id="VAR_004764"
FT   VARIANT         74
FT                   /note="A -> V (in MELAS; dbSNP:rs199476107)"
FT                   /evidence="ECO:0000269|PubMed:11781695"
FT                   /id="VAR_014397"
FT   VARIANT         165
FT                   /note="Y -> C (in dbSNP:rs200933339)"
FT                   /evidence="ECO:0000269|PubMed:1757091"
FT                   /id="VAR_008604"
FT   CONFLICT        102
FT                   /note="L -> F (in Ref. 1; CAA24037)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        134
FT                   /note="L -> F (in Ref. 1; CAA24037)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        159
FT                   /note="T -> P (in Ref. 1; CAA24037)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   174 AA;  18622 MW;  E50CD9F3FAFC600D CRC64;
     MMYALFLLSV GLVMGFVGFS SKPSPIYGGL VLIVSGVVGC VIILNFGGGY MGLMVFLIYL
     GGMMVVFGYT TAMAIEEYPE AWGSGVEVLV SVLVGLAMEV GLVLWVKEYD GVVVVVNFNS
     VGSWMIYEGE GSGLIREDPI GAGALYDYGR WLVVVTGWTL FVGVYIVIEI ARGN
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024