NU6M_LOCMI
ID NU6M_LOCMI Reviewed; 173 AA.
AC Q36425;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 6;
GN Name=ND6;
OS Locusta migratoria (Migratory locust).
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC Acridoidea; Acrididae; Oedipodinae; Locusta.
OX NCBI_TaxID=7004;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8087882; DOI=10.1007/bf00309539;
RA Rippe R.M., Gellissen G.;
RT "The genes for cytochrome b, ND 4L, ND6 and two tRNAs from the
RT mitochondrial genome of the locust, Locusta migratoria.";
RL Curr. Genet. 25:135-141(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8587138; DOI=10.1007/bf00173173;
RA Flook P.K., Rowell C.H.F., Gellissen G.;
RT "The sequence, organization, and evolution of the Locusta migratoria
RT mitochondrial genome.";
RL J. Mol. Evol. 41:928-941(1995).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR EMBL; X80245; CAA56535.1; -; Genomic_DNA.
DR PIR; S40618; S40618.
DR RefSeq; NP_007300.1; NC_001712.1.
DR AlphaFoldDB; Q36425; -.
DR GeneID; 807967; -.
DR CTD; 4541; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..173
FT /note="NADH-ubiquinone oxidoreductase chain 6"
FT /id="PRO_0000118296"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 173 AA; 20117 MW; 206B283EB2AC3CB7 CRC64;
MMKMMIMSSS NLMNINFMKM NHPMSIMMTI IIQTLFISMM TGTMMESFWL SYILLLTFLG
GMMVLFIYIT SIASNEMFKI KINSIIIIVY MMIILSTLMY KLDKTISTEM IKNSEIMNLN
YSINFKEMST SLVKLYNNPT VIITIMMMIY LFITLLAVVK ITNINQGPMR KMS