NU6M_LOXAF
ID NU6M_LOXAF Reviewed; 175 AA.
AC Q9TA18; Q2I3F0;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03923};
DE AltName: Full=NADH dehydrogenase subunit 6;
GN Name=MT-ND6; Synonyms=MTND6, NADH6, ND6;
OS Loxodonta africana (African elephant).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Blood;
RA Hauf J., Waddell P.J., Chalwatzis N., Joger U., Zimmermann F.K.;
RT "The complete mitochondrial genome sequence of the African elephant
RT (Loxodonta africana), phylogenetic relationships of Proboscidea to other
RT mammals and D-loop heteroplasmy.";
RL Zoology 102:184-195(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Blood;
RX PubMed=16448217; DOI=10.1371/journal.pbio.0040073;
RA Rogaev E.I., Moliaka Y.K., Malyarchuk B.A., Kondrashov F.A., Derenko M.V.,
RA Chumakov I., Grigorenko A.P.;
RT "Complete mitochondrial genome and phylogeny of Pleistocene mammoth
RT Mammuthus primigenius.";
RL PLoS Biol. 4:403-410(2006).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03923}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03923};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03924}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03924}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR EMBL; AJ224821; CAA12149.1; -; Genomic_DNA.
DR EMBL; DQ316069; ABC17915.1; -; Genomic_DNA.
DR PIR; T45561; T45561.
DR RefSeq; NP_009290.1; NC_000934.1.
DR AlphaFoldDB; Q9TA18; -.
DR SMR; Q9TA18; -.
DR STRING; 9785.ENSLAFP00000029502; -.
DR Ensembl; ENSLAFT00000038067; ENSLAFP00000029502; ENSLAFG00000033301.
DR GeneID; 808795; -.
DR KEGG; lav:808795; -.
DR CTD; 4541; -.
DR eggNOG; ENOG502S2Q2; Eukaryota.
DR GeneTree; ENSGT00390000003988; -.
DR HOGENOM; CLU_129718_0_0_1; -.
DR InParanoid; Q9TA18; -.
DR OMA; YLGGMMV; -.
DR OrthoDB; 1438416at2759; -.
DR TreeFam; TF343324; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR Gene3D; 1.20.120.1200; -; 1.
DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR Pfam; PF00499; Oxidored_q3; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..175
FT /note="NADH-ubiquinone oxidoreductase chain 6"
FT /id="PRO_0000118298"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 175 AA; 19172 MW; 781003A53A8D9B53 CRC64;
MMYIVFIMSV LYVVGFIGFS SKPSPVYGGM SLVVSGGLGC GIIMGSGGSF LGLVVFLVYL
GGMMVVFGYT IAMATEEYPE TWGSNVVVLG AFLVGLLMEV FMIMWLFSGE HELVGFYFGG
LEDLMVLGEG GFEYVREDYS GGASLYSYGF WFLAMAGWML FVSIFIAIEV TRKRY
