NU6M_MAMPR
ID NU6M_MAMPR Reviewed; 175 AA.
AC Q38PR1;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 54.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03923};
DE AltName: Full=NADH dehydrogenase subunit 6;
GN Name=MT-ND6; Synonyms=MTND6, NADH6, ND6;
OS Mammuthus primigenius (Siberian woolly mammoth).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Mammuthus.
OX NCBI_TaxID=37349;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16362058; DOI=10.1038/nature04432;
RA Krause J., Dear P.H., Pollack J.L., Slatkin M., Spriggs H., Barnes I.,
RA Lister A.M., Ebersberger I., Paeaebo S., Hofreiter M.;
RT "Multiplex amplification of the mammoth mitochondrial genome and the
RT evolution of Elephantidae.";
RL Nature 439:724-727(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Muscle;
RX PubMed=16448217; DOI=10.1371/journal.pbio.0040073;
RA Rogaev E.I., Moliaka Y.K., Malyarchuk B.A., Kondrashov F.A., Derenko M.V.,
RA Chumakov I., Grigorenko A.P.;
RT "Complete mitochondrial genome and phylogeny of Pleistocene mammoth
RT Mammuthus primigenius.";
RL PLoS Biol. 4:403-410(2006).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03923}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03923};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03924}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03924}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR EMBL; DQ188829; ABA29795.1; -; Genomic_DNA.
DR EMBL; DQ316067; ABC17889.1; -; Genomic_DNA.
DR RefSeq; YP_398765.1; NC_007596.2.
DR AlphaFoldDB; Q38PR1; -.
DR SMR; Q38PR1; -.
DR GeneID; 3773152; -.
DR CTD; 4541; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR Gene3D; 1.20.120.1200; -; 1.
DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR Pfam; PF00499; Oxidored_q3; 1.
PE 3: Inferred from homology;
KW Electron transport; Extinct organism protein; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; NAD; Respiratory chain; Translocase;
KW Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..175
FT /note="NADH-ubiquinone oxidoreductase chain 6"
FT /id="PRO_0000232765"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 175 AA; 19154 MW; F70BC575A7F3C82D CRC64;
MMYIVFIMSV LYVVGFIGFS SKPSPVYGGM SLIVSGGLGC GIIMSSGGSF LGLVVFLVYL
GGMMVVFGYT IAMATEEYPE TWGSNVVVLS AFLVGLLMEI FMIVWLFSGE HELVGFYFGG
LEDLVVLGEG SFGYVREDYS GGASLYSYGF WFLAMAGWML FVSIFIAIEV TRKRY