NU6M_MOUSE
ID NU6M_MOUSE Reviewed; 172 AA.
AC P03925;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE EC=7.1.1.2 {ECO:0000269|PubMed:9707444};
DE AltName: Full=NADH dehydrogenase subunit 6;
GN Name=Mtnd6; Synonyms=mt-Nd6, Nd6;
OS Mus musculus (Mouse).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7332926; DOI=10.1016/0092-8674(81)90300-7;
RA Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.;
RT "Sequence and gene organization of mouse mitochondrial DNA.";
RL Cell 26:167-180(1981).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=12954771; DOI=10.1093/nar/gkg739;
RA Bayona-Bafaluy M.P., Acin-Perez R., Mullikin J.C., Park J.S.,
RA Moreno-Loshuertos R., Hu P., Perez-Martos A., Fernandez-Silva P., Bai Y.,
RA Enriquez J.A.;
RT "Revisiting the mouse mitochondrial DNA sequence.";
RL Nucleic Acids Res. 31:5349-5355(2003).
RN [3]
RP FUNCTION, AND CATALYTIC ACTIVITY.
RX PubMed=9707444; DOI=10.1093/emboj/17.16.4848;
RA Bai Y., Attardi G.;
RT "The mtDNA-encoded ND6 subunit of mitochondrial NADH dehydrogenase is
RT essential for the assembly of the membrane arm and the respiratory function
RT of the enzyme.";
RL EMBO J. 17:4848-4858(1998).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor (PubMed:9707444). Essential for the catalytic activity and
CC assembly of complex I (PubMed:9707444). {ECO:0000269|PubMed:9707444}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000269|PubMed:9707444};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03924}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03924}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; J01420; AAB48655.1; -; Genomic_DNA.
DR EMBL; V00711; CAA24089.1; -; Genomic_DNA.
DR EMBL; AY172335; AAN85133.1; -; Genomic_DNA.
DR PIR; A00457; DEMSN6.
DR RefSeq; NP_904339.1; NC_005089.1.
DR PDB; 6G2J; EM; 3.30 A; J=1-172.
DR PDB; 6G72; EM; 3.90 A; J=1-172.
DR PDB; 6ZR2; EM; 3.10 A; J=1-172.
DR PDB; 6ZTQ; EM; 3.00 A; J=1-172.
DR PDB; 7AK5; EM; 3.17 A; J=1-172.
DR PDB; 7AK6; EM; 3.82 A; J=1-172.
DR PDB; 7B93; EM; 3.04 A; J=1-172.
DR PDB; 7PSA; EM; 3.40 A; J=1-172.
DR PDBsum; 6G2J; -.
DR PDBsum; 6G72; -.
DR PDBsum; 6ZR2; -.
DR PDBsum; 6ZTQ; -.
DR PDBsum; 7AK5; -.
DR PDBsum; 7AK6; -.
DR PDBsum; 7B93; -.
DR PDBsum; 7PSA; -.
DR AlphaFoldDB; P03925; -.
DR SMR; P03925; -.
DR BioGRID; 201553; 1.
DR ComplexPortal; CPX-266; Mitochondrial respiratory chain complex I.
DR IntAct; P03925; 1.
DR STRING; 10090.ENSMUSP00000081002; -.
DR PaxDb; P03925; -.
DR PRIDE; P03925; -.
DR Antibodypedia; 35364; 99 antibodies from 20 providers.
DR Ensembl; ENSMUST00000082419; ENSMUSP00000081002; ENSMUSG00000064368.
DR GeneID; 17722; -.
DR KEGG; mmu:17722; -.
DR CTD; 4541; -.
DR MGI; MGI:102495; mt-Nd6.
DR VEuPathDB; HostDB:ENSMUSG00000064368; -.
DR eggNOG; ENOG502S2Q2; Eukaryota.
DR GeneTree; ENSGT00390000003988; -.
DR HOGENOM; CLU_129718_0_0_1; -.
DR InParanoid; P03925; -.
DR OMA; YLGGMMV; -.
DR OrthoDB; 1438416at2759; -.
DR PhylomeDB; P03925; -.
DR TreeFam; TF343324; -.
DR Reactome; R-MMU-611105; Respiratory electron transport.
DR Reactome; R-MMU-6799198; Complex I biogenesis.
DR ChiTaRS; mt-Nd6; mouse.
DR PRO; PR:P03925; -.
DR Proteomes; UP000000589; Mitochondrion.
DR RNAct; P03925; protein.
DR Bgee; ENSMUSG00000064368; Expressed in retinal neural layer and 60 other tissues.
DR ExpressionAtlas; P03925; baseline and differential.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IMP:UniProtKB.
DR GO; GO:0009060; P:aerobic respiration; IC:ComplexPortal.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IMP:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
DR GO; GO:0042776; P:proton motive force-driven mitochondrial ATP synthesis; IC:ComplexPortal.
DR GO; GO:0042220; P:response to cocaine; IEA:Ensembl.
DR GO; GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
DR GO; GO:0035094; P:response to nicotine; IEA:Ensembl.
DR Gene3D; 1.20.120.1200; -; 1.
DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR Pfam; PF00499; Oxidored_q3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; NAD; Reference proteome; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..172
FT /note="NADH-ubiquinone oxidoreductase chain 6"
FT /id="PRO_0000118304"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT HELIX 4..20
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT HELIX 25..45
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT HELIX 50..70
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT TURN 82..84
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT HELIX 86..109
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT STRAND 110..114
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT STRAND 117..119
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT STRAND 121..125
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT HELIX 139..142
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT HELIX 143..145
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT HELIX 149..170
FT /evidence="ECO:0007829|PDB:6ZTQ"
SQ SEQUENCE 172 AA; 18626 MW; 55DE2331AB0A1115 CRC64;
MNNYIFVLSS LFLVGCLGLA LKPSPIYGGL GLIVSGFVGC LMVLGFGGSF LGLMVFLIYL
GGMLVVFGYT TAMATEEYPE TWGSNWLILG FLVLGVIMEV FLICVLNYYD EVGVINLDGL
GDWLMYEVDD VGVMLEGGIG VAAMYSCATW MMVVAGWSLF AGIFIIIEIT RD
