ID   NU6M_MYXGL              Reviewed;         167 AA.
AC   Q9G2W7; O63923;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 6;
GN   Name=MT-ND6; Synonyms=MTND6, NADH6, ND6;
OS   Myxine glutinosa (Atlantic hagfish).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata; Myxini;
OC   Myxiniformes; Myxinidae; Myxininae; Myxine.
OX   NCBI_TaxID=7769;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9541532; DOI=10.1007/pl00006317;
RA   Rasmussen A.S., Janke A., Arnason U.;
RT   "The mitochondrial DNA molecule of the hagfish (Myxine glutinosa) and
RT   vertebrate phylogeny.";
RL   J. Mol. Evol. 46:382-388(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11677623; DOI=10.1007/s002390010250;
RA   Delarbre C., Rasmussen A.S., Arnason U., Gachelin G.;
RT   "The complete mitochondrial genome of the hagfish Myxine glutinosa: unique
RT   features of the control region.";
RL   J. Mol. Evol. 53:634-641(2001).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA75491.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; Y15192; CAA75491.2; ALT_INIT; Genomic_DNA.
DR   EMBL; AJ404477; CAC20660.1; -; Genomic_DNA.
DR   RefSeq; NP_073284.1; NC_002639.1.
DR   AlphaFoldDB; Q9G2W7; -.
DR   SMR; Q9G2W7; -.
DR   GeneID; 802351; -.
DR   CTD; 4541; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR   Pfam; PF00499; Oxidored_q3; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW   Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..167
FT                   /note="NADH-ubiquinone oxidoreductase chain 6"
FT                   /id="PRO_0000118306"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        101
FT                   /note="Y -> F (in Ref. 1; CAA75491)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        142
FT                   /note="C -> G (in Ref. 1; CAA75491)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   167 AA;  17899 MW;  4C75F20E17E1624C CRC64;
     MKIMMILEML FLIGMVILVV DISPYFGALG LIVVSLVGCL IILAKGNSFL SLSLLLIYLG
     GMMVVFSYCT ALVLDLYPTV IVKEVLMKMA LGVLVVVFLG YGGYLKADNG VLSMLGEGGV
     DNSFLGAGVL YGESWLLIVF GCLGLFLALL VILEITKSAE RGAYRVI