NU6M_PIG
ID NU6M_PIG Reviewed; 175 AA.
AC O79882;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03923};
DE AltName: Full=NADH dehydrogenase subunit 6;
GN Name=MT-ND6; Synonyms=MTND6, NADH6, ND6;
OS Sus scrofa (Pig).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9732457; DOI=10.1007/pl00006388;
RA Ursing B.M., Arnason U.;
RT "The complete mitochondrial DNA sequence of the pig (Sus scrofa).";
RL J. Mol. Evol. 47:302-306(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Landrace;
RX PubMed=10433971; DOI=10.1016/s0378-1119(99)00247-4;
RA Lin C.S., Sun Y.L., Liu C.Y., Yang P.C., Chang L.C., Cheng I.C.,
RA Mao S.J.T., Huang M.C.;
RT "Complete nucleotide sequence of pig (Sus scrofa) mitochondrial genome and
RT dating evolutionary divergence within artiodactyla.";
RL Gene 236:107-114(1999).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03923}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03923};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03924}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03924}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ002189; CAA05238.1; -; Genomic_DNA.
DR EMBL; AF034253; AAD34196.1; -; Genomic_DNA.
DR PIR; T10983; T10983.
DR RefSeq; NP_008645.1; NC_000845.1.
DR PDB; 5GPN; EM; 5.40 A; k/l=1-175.
DR PDB; 5GUP; EM; 4.00 A; m=1-175.
DR PDB; 7V2C; EM; 2.90 A; m=1-175.
DR PDB; 7V2D; EM; 3.30 A; m=1-175.
DR PDB; 7V2E; EM; 2.80 A; m=1-175.
DR PDB; 7V2F; EM; 3.10 A; m=1-175.
DR PDB; 7V2H; EM; 2.50 A; m=1-175.
DR PDB; 7V2K; EM; 2.70 A; m=1-175.
DR PDB; 7V2R; EM; 2.60 A; m=1-175.
DR PDB; 7V30; EM; 2.70 A; m=1-175.
DR PDB; 7V31; EM; 2.90 A; m=1-175.
DR PDB; 7V32; EM; 3.20 A; m=1-175.
DR PDB; 7V33; EM; 2.60 A; m=1-175.
DR PDB; 7V3M; EM; 2.90 A; m=1-175.
DR PDB; 7VBL; EM; 2.60 A; m=1-175.
DR PDB; 7VBP; EM; 2.80 A; m=1-175.
DR PDB; 7VC0; EM; 2.60 A; m=1-175.
DR PDB; 7VWL; EM; 2.70 A; m=1-175.
DR PDBsum; 5GPN; -.
DR PDBsum; 5GUP; -.
DR PDBsum; 7V2C; -.
DR PDBsum; 7V2D; -.
DR PDBsum; 7V2E; -.
DR PDBsum; 7V2F; -.
DR PDBsum; 7V2H; -.
DR PDBsum; 7V2K; -.
DR PDBsum; 7V2R; -.
DR PDBsum; 7V30; -.
DR PDBsum; 7V31; -.
DR PDBsum; 7V32; -.
DR PDBsum; 7V33; -.
DR PDBsum; 7V3M; -.
DR PDBsum; 7VBL; -.
DR PDBsum; 7VBP; -.
DR PDBsum; 7VC0; -.
DR PDBsum; 7VWL; -.
DR AlphaFoldDB; O79882; -.
DR SMR; O79882; -.
DR STRING; 9823.ENSSSCP00000019146; -.
DR PaxDb; O79882; -.
DR Ensembl; ENSSSCT00000019687; ENSSSCP00000019146; ENSSSCG00000018092.
DR Ensembl; ENSSSCT00070061689; ENSSSCP00070052589; ENSSSCG00070030652.
DR GeneID; 808512; -.
DR KEGG; ssc:808512; -.
DR CTD; 4541; -.
DR VGNC; VGNC:99797; MT-ND6.
DR eggNOG; ENOG502S2Q2; Eukaryota.
DR GeneTree; ENSGT00390000003988; -.
DR HOGENOM; CLU_129718_0_0_1; -.
DR InParanoid; O79882; -.
DR OMA; YLGGMMV; -.
DR OrthoDB; 1438416at2759; -.
DR TreeFam; TF343324; -.
DR Reactome; R-SSC-611105; Respiratory electron transport.
DR Reactome; R-SSC-6799198; Complex I biogenesis.
DR Proteomes; UP000008227; Mitochondrion.
DR Proteomes; UP000314985; Mitochondrion.
DR Bgee; ENSSSCG00000018092; Expressed in adult mammalian kidney and 45 other tissues.
DR ExpressionAtlas; O79882; baseline and differential.
DR Genevisible; O79882; SS.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR Gene3D; 1.20.120.1200; -; 1.
DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR Pfam; PF00499; Oxidored_q3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; NAD; Reference proteome; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..175
FT /note="NADH-ubiquinone oxidoreductase chain 6"
FT /id="PRO_0000118316"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 175 AA; 19016 MW; DE9EEACD403084F4 CRC64;
MTMYIAFILS TIFVIGFVGF SSKPSPIYGG LGLIVSGGVG CGIVLNFGGS FLGLMVFLIY
LGGMLVVFGY TTAMATEMYP EVWVSNKTVF GAFVSGLMME FCMVYYALKE EEVEIIFKFN
GLGDWVIYDT GDSGFFSEEA MGIAALYSYG TWLVIVTGWS LLIGVVVIME ITRGN
