NU6M_RHISA
ID NU6M_RHISA Reviewed; 149 AA.
AC O99827;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 6;
GN Name=ND6;
OS Rhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus).
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Rhipicephalinae;
OC Rhipicephalus; Rhipicephalus.
OX NCBI_TaxID=34632;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9866211; DOI=10.1093/oxfordjournals.molbev.a025903;
RA Black W.C. IV, Roehrdanz R.L.;
RT "Mitochondrial gene order is not conserved in arthropods: prostriate and
RT metastriate tick mitochondrial genomes.";
RL Mol. Biol. Evol. 15:1772-1785(1998).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR EMBL; AF081829; AAD05528.1; -; Genomic_DNA.
DR PIR; T11164; T11164.
DR RefSeq; NP_008521.1; NC_002074.1.
DR AlphaFoldDB; O99827; -.
DR EnsemblMetazoa; GeneID_808365_df_mr; NP_008521.1; GeneID_808365.
DR GeneID; 808365; -.
DR KEGG; rsan:808365; -.
DR CTD; 4541; -.
DR VEuPathDB; VectorBase:GeneID_808365; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..149
FT /note="NADH-ubiquinone oxidoreductase chain 6"
FT /id="PRO_0000118328"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 149 AA; 17489 MW; C5C9841DE3E3E9C7 CRC64;
MLFSEIKFLI FMSVICLSSS HPILMLSSLI LLTLFLSLIF YFIYQFSIMS MMMILIILGG
MLIIFMYMIS LCPNKKMSFY KKLSVTFTMM LILIPYDSFM TKLEMININK IYSVNFVNMI
ILMMIFLIVM LTIISKNLSW INAPIQKFN